System and method for mixed modality acoustic sampling

Patent metadata

Field	Value
Publication number	US-9724072-B2
Application number	US-201314106356-A
Country	US
Kind code	B2
Filing date	Dec 13, 2013
Priority date	Oct 12, 2011
Publication date	Aug 8, 2017
Grant date	Aug 8, 2017

Abstract

Systems and methods for relaying electrical signals representing acoustic response of a volume of tissue to light and ultrasound stimulation. In an embodiment, a plurality of ultrasound transducers receive acoustic energy from the volume and generate electrical energy, which is transmitted via an electrical path to a relay system. The ultrasound transducers are operated at a wide band frequency of at least 1 MHz to 5 MHz to receive acoustic energy from the volume of tissue responsive to light stimulation and at a narrower band frequency to receive acoustic energy from the volume of tissue responsive to acoustic stimulation. The relay system relays the electrical signals to an optoacoustic system or an ultrasound instrument for further processing depending on whether the electrical signals resulted from ultrasound or light stimulation. In an embodiment, optoacoustic, ultrasound, or other images are generated from the electrical signals and may be coregistered, overlayed, or displayed.

First claim

What is claimed is:

1. A system, comprising:
a plurality of ultrasound transducers capable of generating acoustic output to a volume of tissue and receiving acoustic energy from the volume of tissue;
a first amplifier having an input impedance of 1 K Ω or more;
a second amplifier having an input impedance of less than 1 K Ω;
the system adapted to use the first amplifier to receive acoustic energy from the volume of tissue responsive to light stimulation, and to use the second amplifier to receive acoustic energy from the volume of tissue responsive to acoustic stimulation.

2. The system of claim 1 , wherein the first amplifier has an input impedance of 5 K Ω or more.

3. The system of claim 1 , wherein the second amplifier has an input impedance of 200Ω.

4. The system of claim 3 , wherein the first amplifier has an input impedance of 5 K Ω or more.

5. A method for generating optoacoustic images and ultrasound images of a volume of tissue, comprising:
applying a first impedance to a plurality of ultrasound transducers, the step of applying yielding a first transducer frequency bandwidth;
sampling the plurality of ultrasound transducers to capture optoacoustic return signals in the first transducer frequency bandwidth;
filtering the optoacoustic return signals with common mode stripe filtering;
reconstructing an optoacoustic image from the filtered optoacoustic return signals;
applying a second impedance to the plurality of ultrasound transducers, the step of applying yielding a second transducer frequency bandwidth;
sampling the ultrasound transducers to capture acoustic-generated ultrasound in the second transducer frequency bandwidth; and
producing an ultrasound image by processing the acoustic-generated ultrasound.

6. The method of claim 5 , wherein the first impedance is 1 K Ω or more.

7. The method of claim 6 , wherein the first impedance is 5 K Ω or more.

8. The method of claim 5 , wherein the second impedance is less than 1 K Ω.

9. The method of claim 8 , wherein the first impedance is 1 K Ω or more.

10. The method of claim 9 , wherein the first impedance is 5 K Ω or more.

11. The method of claim 8 , wherein the second impedance is 200 Ω.

12. The method of claim 11 , wherein the first impedance is 1 K Ω or more.

13. The method of claim 12 , wherein the first impedance is 5 K Ω or more.

14. The method of claim 5 , wherein the first transducer frequency bandwidth is from 1 MHz to 5 MHz.

15. The method of claim 5 , wherein the first transducer frequency bandwidth is from 100 KHz to 10 MHz.

16. The method of claim 5 , wherein the first transducer frequency bandwidth is from 50 KHz to 20 MHz.

17. The method of claim 5 , further comprising:
positioning a distal end of a light path to direct at least a substantial portion of its output onto a volume of tissue;
generating at least one pulse of light and causing at least a portion thereof to enter a proximal end of the light path prior to the step of sampling the plurality of ultrasound transducers to capture optoacoustic return signals.

18. The method of claim 17 , further comprising:
coregistering at least a portion of the ultrasound image and at least a portion of the optoacoustic image; and
displaying at least a portion of the ultrasound image and at least a portion of the optoacoustic image on a display.

19. The method of claim 5 , further comprising:
delivering a pulse of energy at a first predominant wavelength to the volume of tissue.

20. The method of claim 19 , wherein the optoacoustic return signals captured in the step of sampling the plurality of ultrasound transducers to capture optoacoustic return signals result from the step of delivering a pulse of energy at the first predominant wavelength.

21. The method of claim 20 , further comprising:
delivering a pulse of energy at a second predominant wavelength to the volume of tissue;
sampling the ultrasound transducers to capture optoacoustic return signals resulting from the step of delivering a pulse of energy at the second predominant wavelength;
filtering the optoacoustic return signals resulting from the step of delivering a pulse of energy at the second predominant wavelength with common mode stripe filtering; and
reconstructing a second optoacoustic image from the filtered optoacoustic return signals resulting from the step of delivering a pulse of energy at the second predominant wavelength.

22. The method of claim 21 , wherein the common mode stripe filtering uses a two-dimensional wavelet transform employing highpass and lowpass wavelet coefficients.

23. The method of claim 21 , further comprising:
forming a parametric map from at least a portion of the optoacoustic image and at least a portion of the second optoacoustic image; and
forming a combined ultrasound and parametric map image by overlaying at least a portion of the parametric map on at least a portion of the ultrasound image.

24. The method of claim 23 , further comprising:
displaying at least the combined ultrasound and parametric map image on a display.

25. The method of claim 23 , further comprising:
displaying at least a portion of the ultrasound image, at least a portion of the optoacoustic image, at least a portion of the second optoacoustic image and at least a portion of the combined ultrasound and parametric map image on a display.

Assignees

• Seno Medical Instr Inc

Inventors

• Herzog Donald G
• Schmid Gregory
• Clingman Bryan
• Zalev Jason
• Ackerman William

Classifications

• G06T12/00

  Tomographic reconstruction from projections · CPC title

• A61B8/5292 Primary

  using additional data, e.g. patient information, image labeling, acquisition parameters · CPC title

• G06T11/003

  Physics · mapped topic

• A61B8/4416 Primary

  related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions · CPC title

• A61B8/5261

  combining images from different diagnostic modalities, e.g. ultrasound and X-ray · CPC title