Microfluidic flame ionization detector

Patent metadata

Field	Value
Publication number	US-9719971-B2
Application number	US-201414483389-A
Country	US
Kind code	B2
Filing date	Sep 11, 2014
Priority date	Sep 13, 2013
Publication date	Aug 1, 2017
Grant date	Aug 1, 2017

Abstract

The present disclosure relates to a microfluidic flame ionization detector for use in small scale separations, such as, for example, microfluidic gas chromatography and microfluidic carbon dioxide based fluid chromatography. In some arrangements, the microfluidic counter-current flame ionization detector employs a non-parallel arrangement for the introduction of combustion gases into the combustion chamber. In other arrangements, the detector housing is configured to incorporate at least one of the detector electrodes within the housing using electrically isolating fittings.

First claim

What is claimed is:

1. A microfluidic flame ionization detector, comprising:
(i) a housing made of metal, ceramic, polymer, or combinations thereof;
(ii) a combustion chamber contained within the housing;
(iii) a microfluidic oxygen inlet contained within the housing and in fluid communication with the combustion chamber;
(iv) a microfluidic effluent and hydrogen inlet contained within the housing and in fluid communication with the combustion chamber;
(v) a polarizer electrode; and
(vi) a collector electrode, wherein the polarizer electrode and collector electrode are electrically isolated from each other at the combustion chamber by an isolator adapted, attached or connected to the housing, wherein the polarizer electrode and the collector electrode provide a potential across the combustion chamber and wherein a portion of the housing functions as at least one of the polarizer electrode or collector electrode.

2. The detector of claim 1 , wherein the portion of the housing functions as the polarizer electrode.

3. The detector of claim 1 , wherein the portion of the housing functions as the collector electrode.

4. The detector of claim 1 , wherein at least two portions of the housing function individually as the polarizer electrode or collector electrode.

5. The detector of claim 1 , wherein the oxygen inlet and the effluent and hydrogen inlet are disposed in a non-parallel arrangement relative to one another.

6. The detector of claim 5 , wherein the oxygen inlet and the effluent and hydrogen inlet are disposed in a substantially opposing relationship at the combustion chamber.

7. The detector of claim 5 , wherein the oxygen inlet and the effluent and hydrogen inlet are disposed at an angle of about 150° to about 210° at the combustion chamber.

8. The detector of claim 1 , wherein the portion of the housing comprises ceramic or a polymer.

9. The detector of claim 1 , further comprising an exhaust port in fluid communication with the combustion chamber.

10. The detector of claim 1 , wherein the polarizer electrode is in communication with a first potential source configured to apply a first potential and the collector electrode is in communication with a second potential source configured to apply a second potential; and the first potential source and the second potential source are configured to have a potential difference between the second potential and the first potential of about 20 V to about 300 V.

11. The detector of claim 1 , wherein the polarizer electrode is in communication with a first potential source configured to apply a first potential and the collector electrode is in communication with a second potential source configured to apply a second potential; and the second potential source is configured such that the second potential is a positive potential and the first potential source is configured such that the first potential is a less positive, a negative potential or a neutral potential.

12. The detector of claim 1 , wherein the polarizer electrode is in communication with a first potential source configured to apply a first potential and the collector electrode is in communication with a second potential source configured to apply a second potential; and the first potential source is configured such that the first potential is a negative potential and the second potential source is configured such that the second potential is a less negative, a positive potential or a neutral potential.

13. The detector of claim 1 , wherein the microfluidic effluent and hydrogen inlet has a cross-sectional area equivalent to an area defined by a round tube having an inner diameter between 40 and 200 μm and supports a hydrogen flow rate through the detector of less than about 100 mL/min.

14. The detector of claim 1 , wherein the microfluidic oxygen inlet has a cross-sectional area equivalent to an area defined by a round tube having an inner diameter between 40 and 200 μm and supports an oxygen flow rate through the detector of less than about 100 mL/min.

15. The detector of claim 14 , wherein the oxygen source is air and the inlet supports an air flow rate through the detector of less than about 50 mL/min.

16. A microfluidic separation system comprising:
(i) a sample injector;
(ii) a separation device in fluid communication and downstream of the injector; and
(iii) the microfluidic flame ionization detector of claim 1 in fluid communication with and downstream of the separation device.

17. The microfluidic separation system of claim 16 , wherein the system is a microfluidic gas chromatographic system or a microfluidic carbon dioxide based chromatographic system.

18. A microfluidic flame ionization detector, comprising:
(i) a housing made of metal, ceramic, polymer, or combinations thereof;
(ii) a combustion chamber contained within the housing;
(iii) a microfluidic oxygen inlet contained within the housing and in fluid communication with the combustion chamber;
(iv) a microfluidic effluent and hydrogen inlet contained within the housing and in fluid communication with the combustion chamber, wherein the oxygen inlet and the effluent and hydrogen inlet are disposed in a non-parallel arrangement relative to one another;
(v) a polarizer electrode; and
(vi) a collector electrode, wherein the second potential is greater than the first potential, wherein the polarizer electrode and collector electrode are electrically isolated from each other at the combustion chamber by an isolator adapted, attached or connected to the housing, wherein the polarizer electrode and collector electrode provide a potential across the combustion chamber, and wherein a portion of the housing functions as at least one of the polarizer electrode or collector electrode.

19. The detector of claim 18 , wherein the oxygen inlet and the effluent and hydrogen inlet are disposed in a substantially opposing relationship at the combustion chamber.

20. The detector of claim 18 , wherein the oxygen inlet and the effluent and hydrogen inlet are disposed at an angle of about 150° to about 210° at the combustion chamber.

Assignees

• Waters Technologies Corp

Inventors

• Fogwill Michael O
• Michienzi Joseph D
• Murphy James P
• Gerhardt Geoff

Classifications

• G01N30/68 Primary

  Flame ionisation detectors · CPC title

• G01N30/6095

  Micromachined or nanomachined, e.g. micro- or nanosize · CPC title

• G01N27/626

  using heat to ionise a gas · CPC title