Flow cell optical detection system

Patent metadata

Field	Value
Publication number	US-9719917-B2
Application number	US-200913130166-A
Country	US
Kind code	B2
Filing date	Nov 23, 2009
Priority date	Nov 24, 2008
Publication date	Aug 1, 2017
Grant date	Aug 1, 2017

Abstract

The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.

First claim

What is claimed is:

1. A flow cell optical detection system with detachable units and optical connectors, comprising:
a first detachable unit including a housing, an interface mounted thereon, and a light source, wherein the light beam from the light source are split into a first light beam and a second light beam by an optical splitter to go through a first optical path in the system and a second optical path in the system respectively;
a second detachable unit including a first detector on the first optical path, wherein the second unit is detachable from the first unit; and
a liquid flow cell including a first unit connector;
wherein the detachable units and the flow cell are configured to provide (i) a first optical connection between the light source and the first detector following the first optical path and (ii) a second optical connection between the light source and the flow cell following the second optical path when the first unit is releasably attached at the interface to the second unit with the flow cell sandwiched in between the first unit and the second unit; and
wherein the second optical connection is provided by the engagement of the first unit connector of the flow cell and a connector of the first unit included in the interface.

2. The system of claim 1 , wherein the second unit includes a second detector on the second optical path.

3. The system of claim 2 , wherein the flow cell is optically connected to the second detector along the second optical path when the first unit is releasably attached to the second unit.

4. The system of claim 1 , wherein the first unit connector is a self-adjusting optical connector.

5. The system of claim 4 , wherein the self-adjusting optical connector is a spring-loaded splicing adaptor.

6. The system of claim 1 , wherein the first light beam is a reference light beam and the first detector is associated with the reference light beam from the light source through the first optical path.

7. The system of claim 2 , wherein the second unit includes electronics configured to process signals from the first and second detectors.

8. The system of claim 7 , wherein the electronics is configured to compute a difference between signals from the first and second detectors.

9. The system of claim 1 , wherein the light source is configured to output one of ultraviolet light and visible light.

10. The system of claim 3 , wherein the second light beam is a sample light beam and the second detector is associated with the flow cell and the sample light beam from the light source through the second optical path.

11. The system of claim 1 , wherein the flow cell further comprising a second unit connector and the second optical connection further comprises the second unit connector releasably engaged with a connector on the second unit such that the flow cell is sandwiched in between the units when the first unit is releasably attached at the interface to the second unit and the flow cell is optically connected to the second detector along the second optical path.

12. The system of claim 11 , wherein the first unit connector and the second unit connector are fiber connectors.

13. The system of claim 1 , wherein the first optical connection is provided through the engagement of a first optical path connector of the first unit on the interface with a counterpart connector of the second unit.

14. A flow cell optical detection system with detachable units and optical connectors, comprising:
a first detachable unit including a housing, an interface mounted thereon, an optical path connector of the first unit on the interface, a flow cell connector on the interface, and a light source, wherein the light beam from the light source are split into a first light beam and a second light beam by an optical splitter to go through a first optical path in the system and a second optical path in the system respectively;
a second detachable unit including a first detector on the first optical path, a second detector on the second optical path, an optical path connector of the second unit, and a flow cell detector of the second unit, wherein the second unit is detachable from the first unit; and
a detachable liquid flow cell including a first unit connector and a second unit connector, wherein the flow cell is detachable from the first and the second units;
wherein the detachable units and the flow cell are configured to provide (i) a first optical connection between the light source and the first detector following the first optical path and (ii) a second optical connection between the light source and the flow cell following the second optical path when the first unit is releasably attached at the interface to the second unit with the flow cell sandwiched in between the first unit and the second unit;
wherein the first optical connection is provided through the engagement of the optical path connector of the first unit on the interface with the optical path connector of the second unit,
wherein the second optical connection is provided by the engagement of the first unit connector of the flow cell and the flow cell connector of the first unit and the second unit connector of the flow cell with the flow cell connector of the second unit such that the flow cell is sandwiched between the units when the first unit is releasably attached to the second unit and the flow cell is optically connected to the second detector along the second optical path, and
wherein the second unit connector is an optical fiber connector and the first unit connector is a self-adjusting optical connector.

15. The system of claim 14 , wherein the self-adjusting optical connector is a spring-loaded splicing adaptor.

16. The system of claim 14 , wherein the first light beam is a reference light beam and the first detector is associated with the reference light beam from the light source through the first optical path and the second light beam is a sample light beam and the second detector is associated with the flow cell and the sample light beam from the light source through the second optical path.

17. The system of claim 14 , wherein the second unit includes electronics configured to process signals from the first and second detectors to compute a difference between signals from the first and second detectors.

18. The system of claim 14 , wherein the light source is configured to output one of ultraviolet light and visible light.

19. A flow cell optical detection system with detachable units and optical connectors, comprising:
a first detachable unit including a housing, an interface mounted thereon, an optical path connector of the first unit on the interface, a flow cell connector on the interface, and a light source, wherein the light beam from the light source are split into a first light beam and a second light beam by an optical splitter to go through a first optical path in the system and a second optical path in the system respectively;
a second detachable unit including a first detector on the first optical path, a second detector on the second optical path, an optical path connector of the second unit, and a flow cell detector of the second unit, wherein the second unit is detachable from the first unit; and
a detachable liquid flow cell including a first unit connector and a second unit connector, wherein the flow cell is detachable from the first and the second units;
wherein the detachable units and the flow cell are configured to provide (i) a first optical connection between the light source and the first detector following the

Assignees

• Frojdh Hakan
• Hornqvist Mikael
• Tormod Stig
• Akerstrom Patrik
• Ge Healthcare Bio Sciences Ab

Inventors

• Frojdh Hakan
• Hornqvist Mikael
• Tormod Stig
• Akerstrom Patrik

Classifications

• G01N21/05

  Flow-through cuvettes (G01N21/09 takes precedence; handling fluid samples G01N1/10) · CPC title

• G01J3/0291

  Housings; Spectrometer accessories; Spatial arrangement of elements, e.g. folded path arrangements · CPC title

• G01N2201/086

  Modular construction, e.g. disconnectable fibre parts · CPC title

• G01N21/33 Primary

  using ultraviolet light (G01N21/39 takes precedence) · CPC title

• G01N2201/0853

  Movable fibre optical member, e.g. for scanning or selecting · CPC title