Triazine derivative and pharmaceutical composition having an analgesic activity comprising the same

Patent metadata

Field	Value
Publication number	US-9718790-B2
Application number	US-201113814346-A
Country	US
Kind code	B2
Filing date	Aug 9, 2011
Priority date	Aug 10, 2010
Publication date	Aug 1, 2017
Grant date	Aug 1, 2017

Abstract

The present invention provides novel compounds having a P2X 3 and/or P2X 2/3 receptor antagonistic effect.
A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I):

wherein

R h and R i are taken together to form a bond; R a and R b and/or R d and R e are taken together to form oxo or the like; R c is hydrogen, substituted or unsubstituted alkyl or the like;

R f is —(CR 4a R 4b ) n —R 2 ; R 4a and R 4b are hydrogen, substituted or unsubstituted alkyl or the like; R 2 is substituted or unsubstjtuted cycloalkyl or the like; n is an integer of 1 to 4; —R g is —X—R 3 ; —X— is —O—, —S— or the like; R 3 is substituted or unsubstituted cycloalkyl or the like,

or its pharmaceutically acceptable salt or a solvate thereof.

First claim

The invention claimed is:

1. A compound selected from

or a pharmaceutically acceptable salt thereof. or a solvate thereof.

2. A pharmaceutical composition comprising at least one compound according to claim 1 , or its pharmaceutically acceptable salt, or solvate thereof.

3. The pharmaceutical composition according to claim 2 , wherein the composition has a P2X 3 and/or P2X 2/3 receptor antagonistic effect.

4. The compound according to claim 1 , having the formula:

or its pharmaceutically acceptable salt, or solvate thereof.

5. The compound according to claim 1 , having the formula:

or its pharmaceutically acceptable salt, or solvate thereof.

6. The compound according to claim 1 , having the formula:

or its pharmaceutically acceptable salt, or solvate thereof.

7. The compound according to claim 1 , having the formula:

or its pharmaceutically acceptable salt, or solvate thereof.

8. The compound according to claim 1 , having the formula:

or its pharmaceutically acceptable salt, or solvate thereof.

9. A pharmaceutical composition comprising a compound according to claim 4 , or its pharmaceutically acceptable salt, or solvate thereof.

10. The pharmaceutical composition according to claim 9 wherein the composition has a P2X 3 and/or P2X 2/3 receptor antagonistic effect.

Assignees

• Kai Hiroyuki
• Horiguchi Tohru
• Asahi Kentaro
• Fujii Yasuhiko
• Shionogi & Co

Inventors

• Kai Hiroyuki
• Horiguchi Tohru
• Asahi Kentaro
• Fujii Yasuhiko

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title

• A61P25/02

  for peripheral neuropathies · CPC title

• C07D401/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title