Mixed disulfide conjugates of thienopyridine compounds and uses thereof

Patent metadata

Field	Value
Publication number	US-9718778-B2
Application number	US-201414758736-A
Country	US
Kind code	B2
Filing date	Jan 6, 2014
Priority date	Jan 9, 2013
Publication date	Aug 1, 2017
Grant date	Aug 1, 2017

Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardiovascular diseases.

First claim

What is claimed is:

1. A compound having Formula I:

or a pharmaceutically acceptable salt or solvate thereof;
wherein R1 is selected from the group consisting of H, —CO—OCH3, and

wherein R2 is selected from the group consisting of

wherein R3 is Chlorine or Fluorine.

2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

3. The pharmaceutical composition of claim 2 , wherein said pharmaceutical composition is configured for intravenous administration.

4. The compound of claim 1 , wherein said compound is selected from the group consisting of

5. The compound of claim 1 , wherein said compound is selected from the group consisting of:

Assignees

• Univ Michigan Regents

Inventors

• Zhang Haoming
• Hollenberg Paul

Classifications

• A61K31/501

  not condensed and containing further heterocyclic rings · CPC title

• C07D401/12 Primary

  linked by a chain containing hetero atoms as chain links · CPC title

• A61K47/542

  Carboxylic acids, e.g. a fatty acid or an amino acid · CPC title

• C07D211/72 Primary

  with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms · CPC title

• A61K31/445

  Non condensed piperidines, e.g. piperocaine · CPC title