Polymeric colorant compositions and methods of use

Patent metadata

Field	Value
Publication number	US-9717798-B2
Application number	US-201214358817-A
Country	US
Kind code	B2
Filing date	Nov 16, 2012
Priority date	Nov 16, 2011
Publication date	Aug 1, 2017
Grant date	Aug 1, 2017

Abstract

A composition is disclosed. The composition comprises at least one polymeric colorant having a polymer component with a colorant component covalently bound thereto, a medicament, and a liquid vehicle. The at least one colorant component does not react directly or indirectly with the medicament. Methods of using the polymeric colorants, including a method for the preparation of skin as a site for a surgical procedure and a method of treating a medical condition, are also provided.

First claim

The invention claimed is:

1. A composition, comprising:
at least one polymeric colorant comprising a polymer component with at least one colorant component covalently bound thereto;
a medicament; and
a liquid vehicle comprising a lower alcohol and water;
wherein the at least one colorant component does not react directly or indirectly with the medicament;
wherein the at least one polymeric colorant is soluble in the composition, and
wherein the at least one polymeric colorant is cationic, nonionic, or zwitterionic.

2. A composition, comprising:
a first polymeric colorant comprising a first polymer component with a first colorant component bound thereto;
a second polymeric colorant comprising a second polymer component with a second colorant component covalently bound thereto;
a medicament; and
a liquid vehicle comprising a lower alcohol and water;
wherein each of the first and second colorant components does not react directly or indirectly with the medicament; wherein at least one polymeric colorant is cationic, nonionic, or zwitterionic and
wherein at least one polymeric colorant is soluble in the composition.

3. The composition of claim 1 , wherein at least one colorant component comprises one or more chromophore and/or one or more fluorophore.

4. The composition of claim 1 , wherein at least one polymer component is derived from vinyl monomers.

5. The composition of claim 1 , wherein at least one polymer component comprises a condensation polymer.

6. The composition of claim 1 , wherein at least one polymer component comprises a polyamine or a polyamide.

7. The composition of claim 1 , wherein the polymer component comprises a natural polymer selected from the group consisting of a polysaccharide and a polypeptide.

8. The composition of claim 1 , wherein the polymer component comprises a synthetic polymer selected from the group consisting of a polyethyleneimine polymer, a polyurethane polymer, a polyether polymer, and a polyacrylate polymer.

9. The composition of claim 1 , wherein at least one polymeric colorant comprises a film-forming polymeric colorant.

10. The composition of claim 7 , wherein the film-forming polymeric colorant is capable of forming a self-supporting film with a dry thickness of 40-50 microns.

11. The composition of claim 1 , further comprising a film-forming polymer.

12. The composition of claim 1 , wherein at least one colorant component comprises a dye selected from the group consisting of a phthalocyanine dye, an acid dye, a basic dye, an azo dye, an anthroquinone dye, a xanthene dye, a triphenylmethane dye, a reactive dye, a direct dye, a vat dye, a sulfur dye, a disperse dye, a mordant dye, and a fluorescent dye.

13. The composition of claim 1 , wherein the medicament is selected from the group consisting of an antimicrobial agent, an antiseptic, an antibiotic, an analgesic, an enzyme, and a mixture of any of two or more of the foregoing medicaments.

14. The composition of claim 13 , wherein the medicament comprises an antimicrobial agent; wherein, when the composition is contacted for a period of time with an area of a surface having a number of cultivable microorganisms present thereon, the concentration of antimicrobial compound in the liquid vehicle is sufficient to reduce the number of cultivable microorganisms on the area of the surface.

15. The composition of claim 14 , wherein the antimicrobial agent comprises a chemical antiseptic compound.

16. A method of preparing skin as a site for a surgical procedure, comprising:
providing a composition that includes at least one polymeric colorant comprising a polymer component with a colorant component covalently bound thereto, an antimicrobial agent, and a liquid vehicle comprising a lower alcohol and water;
wherein the antimicrobial agent is present at a sufficient concentration in the composition such that, when a predetermined quantity of the composition is contacted with a predetermined area of skin having a number of cultivable microorganisms present thereon; the antimicrobial agent is capable of reducing the number of cultivable microorganisms;
wherein the colorant component does not react directly or indirectly with the antimicrobial agent;
wherein the at least one polymeric colorant is soluble in the composition; wherein the at least one polymeric colorant is cationic, nonionic, or zwitterionic;

applying the composition to an area of skin selected for the surgical procedure; and
verifying the area to which the composition was applied by observing on the skin a color associated with the composition.

17. A method of killing microorganisms on mammalian skin prior to a percutaneous procedure comprising:
providing a composition that includes at least one polymeric colorant comprising a polymer component with a colorant component covalently bound thereto, an antimicrobial, and a liquid vehicle comprising a lower alcohol and water;
wherein the antimicrobial is present in a concentration of at least 0.25% wt/wt of the composition;
wherein the colorant component does not react directly or indirectly with the antimicrobial;
wherein the at least one polymeric colorant is soluble in the composition; wherein the at least one polymeric colorant is cationic, nonionic, or zwitterionic;

applying the composition to an area of mammalian skin;
wherein applying the composition to the area reduces the number of cultivable microorganisms on the mammalian skin; and

verifying, by human eye, the area to which the composition was applied by observing on the area a color associated with the composition.

18. The composition of claim 1 , wherein the composition comprises less than 10% volatile organic solvent.

19. The composition of claim 1 , wherein composition is an emulsion.

20. The composition of claim 1 , further comprising a surfactant.

21. The composition of claim 1 , wherein the polymeric colorant is cationic or nonionic.

22. The composition of claim 21 , wherein the medicament is cationic.

Assignees

• 3M Innovative Properties Co

Inventors

• Haddad Louis C
• Hanggi Douglas A
• Olson David B
• Scholz Matthew T
• Zhu Dong-Wei

Classifications

• A61K31/4425

  Pyridinium derivatives, e.g. pralidoxime, pyridostigmine · CPC title

• A01N47/44

  Guanidine; Derivatives thereof · CPC title

• A01N43/40

  six-membered rings · CPC title

• A61K47/34 Primary

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• A61K31/167

  having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol · CPC title