Oral care composition containing ionic liquids

Patent metadata

Field	Value
Publication number	US-9717667-B2
Application number	US-201214654417-A
Country	US
Kind code	B2
Filing date	Dec 20, 2012
Priority date	Dec 20, 2012
Publication date	Aug 1, 2017
Grant date	Aug 1, 2017

Abstract

An oral care composition is provided wherein the composition comprises an ionic liquid, wherein the ionic liquid comprises: a) a quaternary ammonium cation of the formula wherein R 1 , R 2 , R 3 and R 4 are each an organic moiety and may be the same or different, and at least one of R 1 , R 2 , R 3 and R 4 includes a hydroxyl; and b) an anion selected from the group consisting of salicylate, alkylsulfate, sulfate, acetate, halide, phosphate, alkyl phosphate and tosylate; wherein the oral care composition is a mouth rinse, toothpaste, toothpowder, oral bead or strip, fluid-encased dental strip, irrigation fluid, plaque removal liquid, dental floss, hard candy, soft candy, lozenge, chewing gum, or lollipop.

First claim

We claim:

1. An oral care composition for removing or reducing plaque comprising an ionic liquid, wherein the ionic liquid comprises a combination of choline salicylate and tris-(2-hydroxyethyl) methylammonium methylsulfate;
wherein the oral care composition is a mouth rinse; and
wherein the composition comprises a humectant selected from glycerin, sorbitol, propylene glycol and mixtures thereof; and
wherein the composition comprises a surfactant selected from polysorbate 20, polysorbate 80, polyethylene glycol 40 (PEG 40), and a [polyethylene glycol]-[polypropylene glycol]-[polyethylene glycol] (PEG-PPG-PEG) block copolymer.

2. The oral care composition of claim 1 , wherein the ionic liquid is present in the oral care composition in an amount of 8 wt % to 10 wt % based on the total weight of the composition.

3. The oral care composition of claim 1 , wherein the ionic liquid is present in the oral care composition at a concentration of 15 mM to 250 mM.

4. The oral care composition of claim 1 , wherein the oral care composition comprises an abrasive in an amount of less than 0.1 wt % based on the total weight of the composition.

5. The oral care composition of claim 4 , wherein the oral care composition comprises an abrasive in an amount of less than 0.01 wt % based on the total weight of the composition.

6. The oral care composition of claim 1 , wherein the composition is substantially free of any abrasives.

7. The oral care composition of claim 1 , wherein the composition further comprises one or more agents selected from diluents, bicarbonate salts, pH modifying agents, surfactants, foam modulators, thickening agents, viscosity modifiers, sweeteners, flavorants, pigments, an antibacterial agent, anticaries agents, anticalculus agents, tartar control agents, abrasives and mixtures thereof.

8. The oral care composition of claim 1 , wherein the surfactant is present in the oral care composition in an amount of 0.75 wt % to 1.5 wt % based on the total weight of the composition.

9. The oral care composition of claim 1 , wherein the composition comprises glycerin, sorbitol, and propylene glycol.

10. The oral care composition of claim 9 , wherein glycerin is present in an amount of 0.1 wt % to 15 wt % based on the total weight of the composition, sorbitol is present in an amount of 0.1 wt % to 20 wt % based on the total weight of the composition, and propylene glycol is present in an amount of 0.1 wt % to 7 wt % based on the total weight of the composition.

11. The oral care composition of claim 9 , wherein glycerin is present in an amount of 15 wt % to 40 wt % based on the total weight of the composition, sorbitol is present in an amount of 20 wt % to 40 wt % based on the total weight of the composition, and propylene glycol is present in an amount of 10 wt % to 40 wt % based on the total weight of the composition.

12. The oral care composition of claim 7 , wherein the antibacterial agent is cetyl pyridinium chloride (CPC).

13. A method of removing or reducing plaque from the oral cavity of a subject, comprising administering a therapeutically effective amount of the oral care composition according to claim 1 to the subject.

14. The oral care composition of claim 1 , wherein the total amount of ionic liquid present in the composition is between 20 wt % and 40 wt % based on the total weight of the composition.

Assignees

• Colgate Palmolive Co

Inventors

• Patel Madhusudan
• Picquet Guillaume
• Vandeven Mark
• Hassan Mahmoud
• Paredes Rosa

Classifications

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61K31/14

  Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205) · CPC title

• A61K8/368

  with carboxyl groups directly bound to carbon atoms of aromatic rings · CPC title

• A61K2800/30

  Characterized by the absence of a particular group of ingredients · CPC title

• A61K8/416 Primary

  Quaternary ammonium compounds (A61K8/35 takes precedence) · CPC title