Multiple reservoir drug delivery device and methods

Patent metadata

Field	Value
Publication number	US-9717526-B2
Application number	US-201414577291-A
Country	US
Kind code	B2
Filing date	Dec 19, 2014
Priority date	Sep 27, 2012
Publication date	Aug 1, 2017
Grant date	Aug 1, 2017

Abstract

Devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.

First claim

We claim:

1. A method of drug delivery comprising:
deploying a drug delivery device into a mucosal lumen of a human or animal subject, the drug delivery device comprising a first reservoir containing a first drug formulation, a second reservoir containing a second drug formulation, and a porous membrane sidewall adjacent the mucosal lumen, wherein the mucosal lumen is a vagina, cervix, uterus, or bladder of the human or animal subject;
actuating one or more actuation systems, which comprise a microcontroller, to drive the first and second drug formulations out of the first and second reservoirs, respectively, and into the porous membrane sidewall; and
releasing the first and second drug formulations from the porous membrane sidewall to the mucosal lumen.

2. The method of claim 1 , wherein the actuating one or more actuation systems comprises:
actuating a single actuation system to drive the first drug formulation out of the first reservoir; and thereafter
actuating the single actuation system to drive the second drug formulation out of the second reservoir.

3. The method of claim 1 , wherein the actuating one or more actuation systems comprises using at least one electrolytic cell to generate a displacement gas to drive the first and second drug formulations out of the first and second reservoirs.

4. The method of claim 1 , wherein driving the first drug formulation out of the first reservoir is completed before any of the second drug formulation is driven out of the second reservoir.

5. The method of claim 1 , wherein driving the first drug formulation out of the first reservoir overlaps with driving the second drug formulation out of the second reservoir.

6. The method of claim 1 , wherein:
the device comprises a housing configured for intraluminal deployment, the first and second reservoirs being located within the housing,
the first reservoir contains a first plug and the second reservoir contains a second plug, and
actuating the one or more actuation systems to drive the first and second drug formulations out of the first and second reservoirs comprises driving the first and second plugs so as to drive the first and second drug formulations out of the first and second reservoirs.

7. A method of drug delivery comprising:
deploying a drug delivery device into a mucosal lumen of a human or animal subject, the drug delivery device comprising a first reservoir containing a first drug formulation, a second reservoir containing a second drug formulation, and a porous membrane sidewall adjacent the mucosal lumen;
actuating one or more actuation systems to drive the first and second drug formulations out of the first and second reservoirs, respectively, and into the porous membrane sidewall; and
releasing the first and second drug formulations from the porous membrane sidewall to the mucosal lumen;
wherein the porous membrane sidewall comprises a fluidic valve configured such that a critical threshold pressure from about 0.1 psi to about 100 psi is required to drive the first and second drug formulations out of the first and second reservoirs and into the porous membrane sidewall.

8. A method of drug delivery comprising:
deploying a drug delivery device into a mucosal lumen of a human or animal subject, the drug delivery device comprising:
a housing configured for intraluminal deployment,
a first reservoir located within the housing, the first reservoir containing a first drug formulation and a first plug,
a second reservoir located within the housing, the second reservoir containing a second drug formulation and a second plug, and
a porous membrane sidewall adjacent the mucosal lumen, wherein the porous membrane sidewall substantially surrounds the housing;

actuating one or more actuation systems to drive the first and second plugs so as to drive the first and second drug formulations out of the first and second reservoirs, respectively, and into the porous membrane sidewall; and
releasing the first and second drug formulations from the porous membrane sidewall to the mucosal lumen.

Assignees

• Palo Alto Res Ct Inc

Inventors

• Uhland Scott A
• Abhishek Ramkumar
• Peeters Eric
• Curley Timothy J
• Linn Felicia

Classifications

• A61B17/43 Primary

  for artificial insemination · CPC title

• A61M2210/1042

  Alimentary tract (A61M2210/0618 takes precedence) · CPC title

• A61M2210/1475

  Vagina · CPC title

• A61D19/027

  Devices for injecting semen into animals, e.g. syringes, guns, probes · CPC title

• A61K9/0034 Primary

  Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants · CPC title