Radiopharmaceutical concentration measurement system and method

Patent metadata

Field	Value
Publication number	US-9715020-B2
Application number	US-201113639623-A
Country	US
Kind code	B2
Filing date	Apr 11, 2011
Priority date	Apr 9, 2010
Publication date	Jul 25, 2017
Grant date	Jul 25, 2017

Abstract

A system and method for measuring a radioactive concentration of a radiopharmaceutical is disclosed. The system includes a container, an interrogation region associated with the container, a radiation detector, a signal capture device, and a microprocessor system. The radiation detector focuses radiation emitted from the interrogation region, a measurement of which is then obtained by the signal capture device. The microprocessor system is in data communication with the signal capture device, and is capable of calculating the radioactive concentration of the radiopharmaceutical contained in the interrogation region from the radiation measurement obtained by the signal capture device.

First claim

What is claimed is:

1. A system for measuring a radioactive concentration of a radiopharmaceutical, comprising:
a container;
an interrogation region associated with the container;
a radiation detector to focus radiation emitted from the interrogation region;
a signal capture device capable of obtaining a radiation measurement of the radiation emitted from the interrogation region; and
a microprocessor system in data communication with the signal capture device; and
an aperture system having at least one optical element disposed between the interrogation region and the radiation detector,
wherein the microprocessor system is capable of calculating a radioactive concentration of a radiopharmaceutical contained in the interrogation region from the radiation measurement of the radiation emitted from the interrogation region obtained by the signal capture device, and
wherein the aperture system controls a selection of the at least one optical element based on a concentration of the radiopharmaceutical or a type of a radioactive nuclide in the interrogation region.

2. The system of claim 1 wherein the microprocessor system is capable of calculating an identity of a radioactive nuclide associated with the radiopharmaceutical contained in the interrogation region from the radiation measurement of the radiation emitted from the interrogation region obtained by the signal capture device.

3. The system of claim 1 , further comprising a collimator disposed adjacent to the aperture system.

4. The system of claim 1 , wherein the at least one optical element is selected from apertures or attenuating materials.

5. The system of claim 3 , further comprising a motorized system in mechanical communication with the aperture system, wherein the motorized system is capable of moving the aperture system so that the at least one optical element is positioned between the collimator and the radiation detector.

6. The system of claim 1 , wherein the radiation detector includes a crystal sized to an exposed area of the interrogation region and thereby focused to detect the radiation emitted from the interrogation region.

7. The system of claim 1 , further comprising a collimator disposed between the container and the radiation detector, wherein the collimator focuses the radiation detector on the interrogation region.

8. The system of claim 1 , wherein the signal capture device includes at least a means for converting an analog electrical signal into a digital representation thereof, wherein the digital representation is being presented on a signal capture device digital output.

9. The system of claim 1 , wherein the radiation detector further comprises a crystal radiation sensor and an amplifier,
wherein the amplifier receives data from the crystal radiation sensor.

10. The system of claim 1 , further comprising
at least a second radiation detector comprising at least an output,
wherein the container further comprises at least a second interrogation region from which the at least the second radiation detector detects emitted radiation.

11. The system of claim 1 , wherein the microprocessor system is further capable of calculating a half-life of the radiopharmaceutical contained in the interrogation region from a signal capture digital output.

12. The system of claim 1 , wherein the container is a syringe or a pump.

13. A method for measuring a radioactive concentration of a radiopharmaceutical in a concentration measuring system comprising a container including at least one interrogation region, a radiation detector having at least an output, wherein the radiation detector detects a radiation emitted from the at least one interrogation region, a signal capture device including an electronics input and a digital output, the electronics input being in electrical communication with the at least the output of the radiation detector, a microprocessor system in data communication with the digital output of the signal capture device, and an aperture system having at least one optical element disposed between the at least one interrogation region and the radiation detector, wherein the aperture system controls a selection of the at least one optical element based on a concentration of the radiopharmaceutical or a type of a radioactive nuclide in the interrogation region, the method comprising:
exposing the radiation detector to radiation emitted by the radiopharmaceutical contained in the at least one interrogation region;
capturing a signal from the output of the radiation detector through the electronics input of the signal capture device;
converting the signal captured from the output of the radiation detector into a digital representation thereof;
communicating the digital representation from the digital output of the signal capture device to the microprocessor system;
analyzing the digital representation using at least one software module resident on the microprocessor system to provide at least one analysis thereof; and
calculating the radioactive concentration based on a total radiation value calculated by the at least one analysis.

14. The method of claim 13 , wherein the step of analyzing the digital representation further comprises the steps of:
calculating a histogram comprising a plurality of energy values and a plurality of numbers of occurrences of each of the plurality of energy values from a plurality of digital representations;
windowing the histogram into at least one energy value and at least one of the plurality of numbers of occurrences of the at least one energy value thereby creating a windowed histogram;
integrating the at least one of the plurality of numbers of occurrences of the at least one energy value in the windowed histogram thereby creating an integrated value; and
converting the integrated value into the total radiation value.

15. The method of claim 14 , wherein the integrated value is further corrected for non-linearity in the digital representation.

16. The method of claim 13 , wherein the at least one software module comprises a plurality of software modules.

Assignees

• Mabie Marc A
• Mccutchan Larry
• Bouton Chad E
• Dvorsky James E
• Bayer Healthcare Llc

Inventors

• Mabie Marc A
• Mccutchan Larry
• Bouton Chad E
• Dvorsky James E

Classifications

• G01T1/167 Primary

  Measuring radioactive content of objects, e.g. contamination (whole body counters G01T1/163) · CPC title

• G01N33/15

  Medicinal preparations {; Physical properties thereof, e.g. dissolubility} · CPC title

• G01T7/02

  Collecting means for receiving or storing samples to be investigated {and possibly directly transporting the samples to the measuring arrangement; particularly for investigating radioactive fluids (sampling, preparing specimens for investigation in general G01N1/00, G01N1/02; shielded cells or rooms structurally combined with manipulatin devices G21F; measuring of chromatographically separated samples G01N30/00 - G01N30/96)} · CPC title

• G01T1/20

  with scintillation detectors · CPC title

• G01T1/16

  Measuring radiation intensity (G01T1/29 takes precedence {; self-powered detectors G01T3/006; using an ionisation chamber filled with a liquid or solid, e.g. frozen liquid, dielectric G01T3/008}) · CPC title