Multiphase systems and uses thereof

US9714934B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9714934-B2
Application numberUS-201113817976-A
CountryUS
Kind codeB2
Filing dateAug 22, 2011
Priority dateAug 20, 2010
Publication dateJul 25, 2017
Grant dateJul 25, 2017

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  1. Title

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  2. Abstract

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.

First claim

Opening claim text (preview).

What is claimed is: 1. An aqueous two-phase system, comprising: a phase-separated solution comprising two aqueous phases, wherein each of the phases comprises a phase component and has a different density and the phases, taken together, represent a density gradient, and wherein the phase component combination of the two phases is selected from the group consisting of: Number Phase component combinations 1 poly(2-ethyl-2-oxazoline) poly(methacrylic acid) 2 poly(2-ethyl-2-oxazoline) poly(vinyl alcohol) 3 poly(ethylene glycol) poly(methacrylic acid) 6 poly(ethylene glycol) poly(2-ethyl-2-oxazoline) 8 dextran poly(2-ethyl-2-oxazoline) 10 Ficoll poly(methacrylic acid) 11 Ficoll poly(vinyl alcohol) 12 Ficoll poly(2-ethyl-2-oxazoline) 15 polyacrylamide poly(methacrylic acid) 18 polyacrylamide poly(2-ethyl-2-oxazoline) 20 poly(diallyldimethyl ammonium chloride poly(methacrylic acid) 21 poly(diallyldimethyl ammonium chloride poly(acrylic acid) 22 poly(diallyldimethyl ammonium chloride poly(vinyl alcohol) 23 poly(diallyldimethyl ammonium chloride poly(2-ethyl-2-oxazoline) 24 poly(diallyldimethyl ammonium chloride poly(ethylene glycol) 25 dextran sulfate poly(vinyl alcohol) 26 dextran sulfate poly(2-ethyl-2-oxazoline) 28 chondroitin sulfate A poly(methacrylic acid) 29 chondroitin sulfate A poly(vinyl alcohol) 30 chondroitin sulfate A poly(2-ethyl-2-oxazoline) 31 polyethyleneimine poly(methacrylic acid) 32 polyethyleneimine poly(2-ethyl-2-oxazoline) 34 polyethyleneimine Ficoll 35 polyethyleneimine polyacrylamide 36 polyvinylpyrrolidone poly(methacrylic acid) 39 poly(propylene glycol) poly(methacrylic acid) 41 poly(propylene glycol) polyacrylamide 42 poly(2-acrylamido-2-methyl-1-propanesulfonic acid) dextran 43 poly(2-acrylamido-2-methyl-1-propanesulfonic acid) polyvinylpyrrolidone 44 poly(styrene sulfonic acid) poly(2-ethyl-2-oxazoline) 45 poly(styrene sulfonic acid) dextran sulfate 46 diethylaminoethyl-dextran poly(acrylic acid) 47 polyallylamine dextran sulfate 48 alginic acid poly(acrylic acid) 49 alginic acid poly(propylene glycol) 50 (hydroxypropyl)methyl cellulose poly(diallyldimethyl ammonium chloride 51 (hydroxypropyl)methyl cellulose poly(propylene glycol) 52 carboxy-polyacrylamide poly(methacrylic acid) 53 carboxy-polyacrylamide poly(vinyl alcohol) 54 carboxy-polyacrylamide polyethyleneimine 55 hydroxyethyl cellulose dextran 56 hydroxyethyl cellulose Ficoll 57 methyl cellulose Ficoll 58 Zonyl poly(methacrylic acid) 59 Zonyl dextran 60 Zonyl polyacrylamide 61 Brij poly(2-ethyl-2-oxazoline) 62 Brij Ficoll 63 Brij polyallylamine 64 Tween poly(methacrylic acid) 65 Tween poly(vinyl alcohol) 66 Tween poly(2-ethyl-2-oxazoline) 69 Tween Ficoll 71 Tween polyallylamine 72 Tween hydroxyethyl cellulose 73 Triton poly(methacrylic acid) 74 Triton poly(acrylic acid) 75 Triton poly(2-ethyl-2-oxazoline) 77 Triton Ficoll 78 Triton polyacrylamide 79 Triton polyallylamine

Assignees

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Classifications

  • involving compounds localised on the membrane of tumour or cancer cells · CPC title

  • by sink-float separation · CPC title

  • Differential sedimentation · CPC title

  • Water · CPC title

  • by changing the physical or chemical properties of the medium or immunochemicals, e.g. temperature, density, pH, partitioning · CPC title

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What does patent US9714934B2 cover?
A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase sys…
Who is the assignee on this patent?
Mace Charles R, Halatci Ozge Akbulut, Kumar Ashok A, and 3 more
What technology area does this patent fall under?
Primary CPC classification G01N33/491. Mapped technology areas include Physics.
When was this patent published?
Publication date Tue Jul 25 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).