Cyclopropaneamine compound
US-9278931-B2 · Mar 8, 2016 · US
US9714241B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9714241-B2 |
| Application number | US-201615203551-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 6, 2016 |
| Priority date | Apr 11, 2014 |
| Publication date | Jul 25, 2017 |
| Grant date | Jul 25, 2017 |
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The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, spinocerebellar degeneration (e.g., dentatorubural pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.
Opening claim text (preview).
The invention claimed is: 1. The compound represented by 4-((1S,2R)-2-(cyclobutylamino)cyclopropyl)-5-methyl-N-(1-methyl-1H-pyrazol-4-yl)thiophene-2-carboxamide or a salt thereof. 2. A medicament comprising the compound according to claim l or a salt thereof.
containing three or more hetero rings · CPC title
containing three or more hetero rings · CPC title
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms · CPC title
Thiophene-2-carboxylic acid · CPC title
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title
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