Method and apparatus for manufacturing liquid microspheres

Patent metadata

Field	Value
Publication number	US-9713802-B2
Application number	US-47390609-A
Country	US
Kind code	B2
Filing date	May 28, 2009
Priority date	Jan 13, 2009
Publication date	Jul 25, 2017
Grant date	Jul 25, 2017

Abstract

The present invention provides microsphere manufacturing method and apparatus capable of stable obtaining microspheres of a desired size and reducing facility cost. According to the method and the apparatus, to manufacture microspheres made of a second liquid in a first liquid, the first liquid is supplied into a first channel to flow therein and the second liquid is supplied to an intermediate part of the first channel through a second channel. The supply velocities of the first and second liquids are set such that the second liquid closes the first channel and the closing part of the second liquid is cut off due to a pressure difference between an upstream side and a downstream side to form microspheres.

First claim

What is claimed is:

1. A method for manufacturing microspheres made of a second liquid in a first liquid, comprising:
a step of providing a channel forming body, which channel forming body provides channels including a first channel and a second channel joined to an intermediate part of the first channel at a junction point, the first channel having a special inner wall surface throughout a specific region of the first channel and another inner wall surface in another region of the first channel which is upstream or downstream of said specific region in a direction of flow of the first liquid in the first channel, the specific region including the junction point, wherein the special inner wall surface is formed with a convexo-concave pattern providing an affinity with the second liquid higher than that of the another inner wall surface in the another region of the first channel;
a step of supplying the first liquid into the first channel to flow the first liquid in the first channel at a first supply velocity;
a step of supplying the second liquid to the intermediate part of the first channel at the junction point through the second channel joined to the first channel at a second supply velocity with a ratio of the first supply velocity to the second supply velocity, the ratio being sufficiently low that the second liquid supplied to the first channel at the junction point remains at the junction point until the second liquid forms a closing part which completely closes the first channel; and
a step of promoting the second liquid to stay at the junction point in the specific region by the affinity of the special inner surface in the specific region with the second liquid, to thereby generate a pressure difference between a pressure at an upstream side of the closing part of the second liquid and a pressure at a downstream side of the closing part of the second liquid in the first channel, the pressure difference cutting off the closing part from the other part of the second liquid in the second channel to thereby move the closing part to the downstream side of the first channel to form microspheres of the second liquid.

2. A method for chemically reacting a first liquid and a second liquid, comprising:
a step of providing a channel forming body, which channel forming body forms channels including a first channel and a second channel joined to an intermediate part of the first channel at a junction point, the first channel having a special inner wall surface throughout a specific region of the first channel and another inner wall surface in another region of the first channel which is upstream or downstream of said specific region in a direction of flow of the first liquid in the first channel, the specific region including the junction point, the special inner wall surface being formed with a convexo-concave pattern providing an affinity with the second liquid higher than that of the another inner wall surface in the another region of the first channel;
a step of supplying the first liquid into the first channel to flow it in the first channel at a first supply velocity;
a step of supplying the second liquid to the intermediate part of the first channel at the junction point through the second channel joined to the first channel at a second supply velocity with a ratio of the first supply velocity to the second supply velocity, the ratio being so low as to allow the second liquid supplied to the first channel at the junction point to remain at the junction point until the second liquid forms a closing part which completely closes the first channel;
a step of promoting the second liquid to stay at the junction point in the specific region by the affinity of the special inner surface in the specific region with the second liquid to thereby generate a pressure difference between a pressure at an upstream side of the closing part of the second liquid and a pressure at a downstream side of the closing part of the second liquid in the first channel, the pressure difference cutting off the closing part from the other part of the second liquid in the second channel to thereby move the closing part to the downstream side of the first channel to form microspheres of the second liquid; and
a step of causing a chemical reaction between the first and second liquids while the microspheres made of the second liquid flow in the first channel downstream of the junction point.

3. The method according to claim 2 , wherein the first channel further comprises a reaction region located downstream of the specific region, in the flow direction of the first liquid, for a chemical reaction of the first liquid and the second liquid, wherein the special inner wall surface is also provided to the reaction region.

Assignees

• Ban Hiroyuki
• Noishiki Koji
• Okada Kazuto
• Yamamoto Seiichi
• Kobe Steel Ltd

Inventors

• Ban Hiroyuki
• Noishiki Koji
• Okada Kazuto
• Yamamoto Seiichi

Classifications

• B01J2219/00889

  Mixing · CPC title

• B01J2219/00891

  Feeding or evacuation · CPC title

• B01J2219/00984

  Residence time · CPC title

• B01J19/0093 Primary

  Microreactors, e.g. miniaturised or microfabricated reactors (laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027) · CPC title

• B01J2219/00837

  comprising coatings other than catalytically active coatings · CPC title