Electrostatic-assisted fiber spinning method and production of highly aligned and packed hollow fiber assembly and membrane

Patent metadata

Field	Value
Publication number	US-9713521-B2
Application number	US-201514824894-A
Country	US
Kind code	B2
Filing date	Aug 12, 2015
Priority date	Apr 21, 2010
Publication date	Jul 25, 2017
Grant date	Jul 25, 2017

Abstract

The invention provides a highly aligned and closely packed hollow fiber assembly, wherein the assemblies of fibrous membrane has a width-to-fiber diameter ratio (W/d) larger than 10 and the orientation of the fibers is no larger than +/−10°. Also provided is an electrospinning process for the preparation of the fiber assembly of the invention and its applications.

First claim

What is claimed is:

1. A highly aligned and closely packed electrospun fiber assembly, wherein at least five (5) electrospun fibers are packed together to form a single layer and an orientation of the electro spun fibers is no greater than +/−5° relative to a longitudinal axis of the assembly, wherein the electrospun fibers are connected so that the electrospun fibers are aligned and closely packed to form the single layer, and wherein the alignment of the fibers is in the orientation no greater than +/−5°;
wherein the fiber assembly is composed of a polymer selected from a group consisting of ethylene oxide, polyethylene oxide, ethylene glycol, polyethylene glycol, poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(ethylene oxide) (PEO), nylon, polyesters, polyamides, poly(amino acids), polyimides, polyethers, polyketones, polyurethanes, polycaprolactones, polyacrylonitriles, polyaramides, conjugated polymers, poly(2-methoxy, 5 ethyl (2′ hexyloxy) para-phenylene vinylene) (MEH-PPV), polyphenylenevinylenes, polyarylene-vinylenes, polythienolene-vinylenes, polypyrrolo-vinylenes, polyheteroarylene-vinylenes, polyanilines, polyphenylenes, polyarylenes, polythiophenes, polypyrroles, polyheteroarylenes, polyphenylene-ethynylenes, polyarylene-ethynylenes, polythieno-ethynylenes, polyheteroarylene-ethynylenes, and mixtures thereof; and
wherein an average wall thickness of each fiber is about 1 to about 5 μm.

2. The fiber assembly of claim 1 , wherein at least 20 fibers are packed together to form the single layer.

3. The fiber assembly of claim 1 , wherein at least 50 fibers pack together to form the single layer.

4. The fiber assembly of claim 1 , wherein the number of the fibers packed together in the fiber assembly ranges from 5 to 200.

5. The fiber assembly of claim 1 , wherein the orientation of the fibers is no larger than +/−2°.

6. The fiber assembly of claim 1 , wherein the orientation of the fibers is about +/−1° to about +/−5°.

7. The fiber assembly of claim 1 , wherein the orientation of the fibers is about +/−1° to about +/−4°.

8. The fiber assembly of claim 1 , wherein the fibers are hollow.

9. The fiber assembly of claim 1 , wherein a length-to-diameter ratio (L/d) of each fiber is larger than about 20.

10. The fiber assembly of claim 1 , wherein a L/d of each fiber is larger than about 100.

11. The fiber assembly of claim 1 , wherein a L/d of each fiber is larger than about 1,000.

12. The fiber assembly of claim 1 , wherein a L/d of each fiber is about 20 to about 10,000.

13. The fiber assembly of claim 1 , wherein an average wall thickness of each fiber is about 1 to about 3 μm.

14. The fiber assembly of claim 1 , which can be used in medical tissue engineering and filtration unit.

15. The fiber assembly of claim 14 , wherein the medical tissue engineering includes scaffold, nerve guide conduit and vascular tube.

16. The fiber assembly of claim 1 , which can be in situ seeded with cells.

17. The fiber assembly of claim 16 , wherein the cells are selected from a group consisting of nerve cells, epithelial cells, endothelial cells, fibroblasts, myoblasts, chondroblasts, osteoblasts, neural stem cells, Schwann cells, astrocytes, oligodendrocytes and their precursors, adrenal chromaffin cells, and the mixtures thereof.

18. The fiber assembly of claim 1 , wherein an average diameter of each fiber is about 25 to about 100 μm.

19. The fiber assembly of claim 1 , wherein an average diameter of each fiber is about 25 to about 80 μm.

20. The fiber assembly of claim 1 , wherein an average diameter of each fiber is about 25 to about 70 μm.

21. The fiber assembly of claim 1 , wherein an average diameter of each fiber is about 25 to about 60 μm.

22. The fiber assembly of claim 1 , wherein an average diameter of each fiber is about 25 to about 50 μm.

23. The fiber assembly of claim 1 , wherein the biodegradable polymer is poly(lactic acid) (PLA), poly(glycolic acid) (PGA), polycarprolactone, polydioxane, poly(glycolide-co-lactide) (PGA-co-PLA) or poly(lactic-co-glycolic acid) (PLA-co-PGA).

24. The fiber assembly of claim 1 , wherein the fibers of the fiber assembly have a core-shell structure.

25. The fiber assembly of claim 24 , wherein the core-shell structure having a shell layer which is composed of poly-L-lactic acid, poly(lactic-co-glycolic acid) or a mixture thereof and the core layer is composed of polyethylene glycol, polyethylene oxide, PF127 or a mixture thereof.

Assignees

• Univ Taipei Medical

Inventors

• Chen Chien-Chung
• Yang Jen-Chang
• Lu Jen-Chieh
• Lee Sheng-Yang

Classifications

• Y10T428/268

  Monolayer with structurally defined element · CPC title

• Y10T428/249924

  Noninterengaged fiber-containing paper-free web or sheet which is not of specified porosity · CPC title

• D01D5/0069

  characterised by the spinning section, e.g. capillary tube, protrusion or pin · CPC title

• D01D5/0076

  characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid (D01D5/0046 takes precedence) · CPC title

• B01D2323/39

  Electrospinning · CPC title