Bioinformatic processing systems and methods

Patent metadata

Field	Value
Publication number	US-9710597-B2
Application number	US-201615067711-A
Country	US
Kind code	B2
Filing date	Mar 11, 2016
Priority date	Apr 24, 2013
Publication date	Jul 18, 2017
Grant date	Jul 18, 2017

Abstract

The present disclosure relates to systems and methods for facilitating trusted handling of genomic and/or other bioinformatic information. Certain embodiments may facilitate policy-based governance of access to and/or use of bioinformatic information, improved interaction with and/or use of distributed bioinformatic information, parallelization of various processes involving bioinformatic information, and/or reduced user involvement in bioinformatic workflow processes, and/or the like. Further embodiments may provide for memoization processes that may persistently store final and/or intermediate results of computations performed using genomic data for use in connection with future computations.

First claim

What is claimed is:

1. A method for performing trusted computations on genomic data performed by a distributed computing system comprising a processor and a non-transitory computer-readable storage medium storing instructions that, when executed by the processor, cause the system to perform the method, the method comprising:
receiving a first request, comprising a first set of one or more pieces of identification information, from a user system to perform a computation by a computational module associated with a first computing domain of the distributed computing system, whereby the computation comprises analyzing a genomic data set to determine a particular genomic feature of the genomic data set;
determining, based on the first set of one or more pieces of identification information, that a result of a prior computation using the first set of one or more pieces of identification information is not stored in a persistent storage associated with a second computing domain of the distributed computing system;
storing information associated with the first set of one or more pieces of identification information in the persistent storage;
generating, based on the first set of one or more pieces of identification information, a result of the computation using the genomic data set;
storing the result of the computation in the persistent storage; and
sending the result of the computation to the user system.

2. The method of claim 1 , wherein the method further comprises:
receiving a second request to perform the computation by the computational module using the genomic data set, the second request comprising the first set of one or more pieces of identification information;
determining, based on the first set of one or more pieces of identification information, that the result of the computation is stored in the persistent storage;
accessing the result of the computation from the persistent storage; and
sending the result of the computation to a system associated with the second request.

3. The method of claim 1 , wherein the first set of one or more pieces of identification information comprises authentication information.

4. The method of claim 1 , wherein the first set of one or more pieces of identification information comprises policy information associated with the genomic data set.

5. The method of claim 1 , wherein the first set of one or more pieces of identification information comprises a cohort selection associated with the genomic data set.

6. The method of claim 1 , wherein the first set of one or more pieces of identification information comprises instruction information associated with the computation.

7. The method of claim 1 , wherein the method further comprises associating the information associated with the first set of one or more pieces of identification information with the result of the computation in the persistent storage.

8. The method of claim 1 , wherein the information associated with the first set of one or more pieces of identification information comprises a computed hash of the first set of one or more pieces of identification information.

9. The method of claim 1 , wherein the information associated with the first set of one or more pieces of identification information comprises the first set of one or more pieces of identification information.

10. The method of claim 1 , wherein the genomic data set comprises human genomic data.

11. The method of claim 1 , wherein determining that the result of a prior computation is not stored in the persistent storage comprises:
computing a hash of the first set of one or more pieces of identification information;
determining that the hash of the first set of one or more pieces of identification information is not stored in the persistent storage; and
based on the determination, determining that the result of the prior computation is not stored in the persistent storage.

Assignees

• Intertrust Tech Corp

Inventors

• Nilsson Jarl
• Carey William Knox

Classifications

• H04W12/02

  Protecting privacy or anonymity, e.g. protecting personally identifiable information [PII] · CPC title

• G06F16/2474

  Sequence data queries, e.g. querying versioned data · CPC title

• G06F16/2255

  Hash tables · CPC title

• H04L63/08

  for authentication of entities (cryptographic mechanisms or cryptographic arrangements for entity authentication H04L9/32) · CPC title

• G06F16/24

  Querying · CPC title