Exosome extracellular vesicles and methods of use
US-12109310-B2 · Oct 8, 2024 · US
US9708369B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9708369-B2 |
| Application number | US-201514735648-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 10, 2015 |
| Priority date | Oct 26, 2011 |
| Publication date | Jul 18, 2017 |
| Grant date | Jul 18, 2017 |
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Disclosed are methods of altering metabolism of phosphate in a livestock via an antibody. The methods involve the development of an antibody against FGF-23 for the purpose of reducing phosphate excretion by an animal.
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What is claimed is: 1. A polypeptide consisting of an amino acid sequence comprising a NP-1 epitope selected from the group consisting of SEQ ID NO:25, SEQ ID NO:26, and SEQ ID NO:27, wherein the polypeptide is conjugated to a carrier protein. 2. A composition comprising a polypeptide and a carrier protein, wherein the polypeptide consists of an amino acid sequence comprising a NP-1 epitope selected from the group consisting of SEQ ID NO:25, SEQ ID NO:26, and SEQ ID NO:27, wherein the polypeptide is conjugated to the carrier protein and wherein the carrier protein is selected from the group consisting of bovine gamma globulin, FGF-23, bovine serum albumin, keyhole limpet hemocyanin, and ovalbumin. 3. The composition of claim 2 , further comprising an adjuvant selected from the group consisting of Freund's complete adjuvant and Freund's incomplete adjuvant. 4. The composition of claim 3 , wherein the composition comprises from about 50 micrograms to about 6 milligrams of the polypeptide conjugate.
Immunostimulants · CPC title
the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines · CPC title
against growth factors {; against growth regulators} · CPC title
Fibroblast growth factor [FGF] · CPC title
Albumin; Keyhole limpet haemocyanin [KLH] · CPC title
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