Process for preparing 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or pharmaceutically acceptable salt thereof
US-9101626-B2 · Aug 11, 2015 · US
Phenyl-piperazine derivatives as serotonin reuptake inhibitors
US9708280B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9708280-B2 |
| Application number | US-201514744197-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 19, 2015 |
| Priority date | Oct 4, 2001 |
| Publication date | Jul 18, 2017 |
| Grant date | Jul 18, 2017 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
First claim
Opening claim text (preview).
The invention claimed is: 1. A process for the manufacture of a compound represented by formula Ia or an acid addition salt thereof: wherein s is 2; and each R 3 is independently halogen, cyano, nitro, C 1-6 -alkyl, or C 1-6 -alkyloxy, the process comprising deprotection or cleavage from a polymer support of a compound of formula IIa: wherein R′″ is tert-butyl, methyl, ethyl, allyl, or benzyl or is a solid supported carbamate group. 2. The process of claim 1 , wherein each R 3 is independently C 1-6 -alkyl. 3. The process of claim 1 , wherein the compound of formula Ia is 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine. 4. A process for the manufacture of a compound represented by formula Ia or an acid addition salt thereof: wherein s is 2; and each R 3 is independently halogen, cyano, nitro, C 1-6 -alkyl, or C 1-6 -alkyloxy, the process comprising: chemical transformation of to the corresponding diazonium compound; and reacting the diazonium compound with to form the compound of formula Ia. 5. The process of claim 4 , wherein each R 3 is independently C 1-6 -alkyl. 6. The process of claim 4 , wherein the compound of formula Ia is 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine.
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Antidepressants · CPC title
Anxiolytics · CPC title
Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia · CPC title
Drugs for disorders of the nervous system · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9708280B2 cover?
- The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
- Who is the assignee on this patent?
- H Lundbeck As
- What technology area does this patent fall under?
- Primary CPC classification C07D295/096. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 18 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).