Process for regeneration of spent zirconium phosphate for reuse in sorbent treatments

Patent metadata

Field	Value
Publication number	US-9707329-B2
Application number	US-201314060761-A
Country	US
Kind code	B2
Filing date	Oct 23, 2013
Priority date	Oct 23, 2013
Publication date	Jul 18, 2017
Grant date	Jul 18, 2017

Abstract

A method is provided for regenerating spent zirconium phosphate for reuse in sorbent dialysis treatments or other re-uses as a sorbent material. The method includes contacting spent zirconium phosphate with an aqueous disinfectant solution having at least one antimicrobial agent, and treating the resulting disinfected zirconium phosphate with an acidic solution to provide a treated zirconium phosphate that can be re-used as a sorbent material. Sorbent cartridge products containing the regenerated spent zirconium phosphate are also provided. Methods and systems for sorbent dialysis which re-use the regenerated zirconium phosphate such as part of sorbent cartridges, additionally are provided.

First claim

What is claimed is:

1. A method for regeneration of spent zirconium phosphate comprising:
a) contacting spent zirconium phosphate particles with an aqueous disinfectant solution comprising at least one antimicrobial agent to provide a slurry of disinfected zirconium phosphate;
b) filtering off aqueous fluid phase from the slurry of disinfected zirconium phosphate to isolate a wet cake containing disinfected zirconium phosphate;
c) washing the wet cake containing the disinfected zirconium phosphate to provide washed disinfected zirconium phosphate; and
d) treating the washed disinfected zirconium phosphate with an acidic solution to provide a treated zirconium phosphate.

2. The method of claim 1 , wherein the treating removes cations adsorbed on the disinfected zirconium phosphate.

3. The method of claim 1 , wherein the washing of the wet cake containing the disinfected zirconium phosphate comprises washing the wet cake containing the disinfected zirconium phosphate with an aqueous solution to obtain a halogen ppm level of about 0 ppm in wash effluent.

4. The method of claim 1 , further comprising:
e) filtering the treated zirconium phosphate to isolate a wet cake containing the treated zirconium phosphate; and
f) washing the wet cake containing the treated zirconium phosphate to provide washed treated zirconium phosphate, wherein said washing the washed treated zirconium phosphate is with an aqueous solution.

5. The method of claim 4 , further comprising g) titrating the washed treated zirconium phosphate to a pH of about 5.5 to about 8.5 to provide titrated zirconium phosphate.

6. The method of claim 5 , further comprising:
h) filtering the titrated zirconium phosphate to isolate a wet cake containing the titrated zirconium phosphate; and
i) washing the wet cake containing the titrated zirconium phosphate to provide washed titrated zirconium phosphate.

7. The method of claim 6 , further comprising j) drying the washed titrated zirconium phosphate to provide dried regenerated zirconium phosphate.

8. The method of claim 4 , wherein the washing of the wet cake containing the treated zirconium phosphate comprises washing the wet cake containing the treated zirconium phosphate until wash effluent of the washing has a total dissolved solids (TDS) level of no greater than about 1200 ppm.

9. The method of claim 6 , wherein the washing of the wet cake containing the titrated zirconium phosphate comprises washing the wet cake containing the titrated zirconium phosphate until the washed titrated zirconium phosphate has a total dissolved solids (TDS) level of no greater than about 500 ppm.

10. The method of claim 7 , wherein the dried regenerated zirconium phosphate has a moisture level of from about 14% to about 18% by weight.

11. The method of claim 7 , wherein the dried regenerated zirconium phosphate comprises free-flowing particles thereof.

12. The method of claim 1 , wherein the antimicrobial agent comprises a chlorine-containing compound.

13. The method of claim 1 , wherein the antimicrobial agent comprises hypohalite salt.

14. The method of claim 1 , wherein the antimicrobial agent comprises alkali metal hypochlorite, alkaline earth metal hypochlorite, or any combinations thereof.

15. The method of claim 1 , wherein the acidic solution comprises HCl, HBr, HF, HI, HClO, HClO 3 , HClO 4 , HBrO 4 , HNO 3 , H 2 SO4, or any combinations thereof.

16. The method of claim 1 , wherein the acidic solution comprises HCl.

17. A method for regeneration of spent zirconium phosphate comprising:
a) contacting spent zirconium phosphate particles with an aqueous disinfectant solution comprising at least one antimicrobial agent to provide a slurry of disinfected zirconium phosphate;
b) filtering off aqueous fluid phase from the slurry to isolate a wet cake containing the disinfected zirconium phosphate; and
c) washing the wet cake containing the disinfected zirconium phosphate to provide washed disinfected zirconium phosphate with the washing providing a level of the antimicrobial agent in wash effluent of the washing of no greater than a first preselected value;
d) treating the washed disinfected zirconium phosphate with an acidic solution to remove cations adsorbed thereon to provide a treated zirconium phosphate;
e) filtering the treated zirconium phosphate to isolate a wet cake containing the treated zirconium phosphate; and
f) washing the treated zirconium phosphate to provide washed treated zirconium phosphate with the washing providing a first total dissolved solids (TDS) level in wash effluent of the washing of no greater than a second preselected value;
g) titrating the washed treated zirconium phosphate to a pH of about 5.5 to about 8.5 to provide titrated zirconium phosphate;
h) filtering the titrated zirconium phosphate to isolate a wet cake containing the titrated zirconium phosphate; and
i) washing the titrated zirconium phosphate to provide washed titrated zirconium phosphate having a second total dissolved solids (TDS) level of no greater than a third preselected value; and
j) drying the washed titrated zirconium phosphate to provide dried regenerated zirconium phosphate.

Assignees

• Fresenius Medical Care Holdings Inc

Inventors

• Merchant Stephen A
• Adams Kerissa

Classifications

• B01J49/53

  for cationic exchangers · CPC title

• A61M1/1696 Primary

  with dialysate regeneration · CPC title

• B01J20/0211

  Compounds of Ti, Zr, Hf · CPC title

• A61K33/42

  Phosphorus; Compounds thereof · CPC title

• C01B25/372

  of titanium, vanadium, zirconium, niobium, hafnium or tantalum · CPC title