Sorbent cartridge to measure solute concentrations

Patent metadata

Field	Value
Publication number	US-9707328-B2
Application number	US-201313791755-A
Country	US
Kind code	B2
Filing date	Mar 8, 2013
Priority date	Jan 9, 2013
Publication date	Jul 18, 2017
Grant date	Jul 18, 2017

Abstract

A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid. The system has a sorbent regeneration system for regeneration of the fluid and has a sorbent cartridge that has at least one material layer. The fluid is conveyed through the sorbent cartridge and contacts at least one sensor after having contacted at least one material layer.

First claim

The invention claimed is:

1. A sorbent based monitoring system for measuring a solute concentration of at least one component of a fluid, comprising:
a sorbent regeneration system for regeneration of the fluid, wherein the sorbent regeneration system has a plurality of material layers formed in one or more regeneration module, wherein the fluid is conveyed to the one or more regeneration module;
wherein a part of a primary flow stream contacts at least two sensors; wherein a first sensor, upstream from at least one material layer in the one or more regeneration module, contacts fluid that has not contacted a specified material layer, and a second sensor, downstream from the specified material layer, contacts fluid that has contacted the specified material layer; and
a processor determining a solute concentration in the fluid based on a difference between a measurement from the first sensor and the second sensor.

2. The system of claim 1 , wherein the fluid is a dialysate for hemodialysis or hemodiafiltration and the one or more regeneration module receives a spent dialysate containing at least one species from the dialysate outlet port of a dialyzer and removes at least a portion of a species from the dialysate to regenerate the dialysate for recirculation of at least a portion of the regenerated dialysate to the dialysate inlet port of a dialyzer.

3. The system of claim 1 , wherein the fluid is a filtrate and the one or more regeneration module receives a filtrate containing at least one species from the filtrate outlet port of a hemofilter and removes at least a portion of a species from the filtrate to regenerate a replacement fluid for return of at least a portion of the regenerated replacement fluid to a conduit of an extracorporeal circuit.

4. The system of claim 1 , wherein the fluid is a dialysate for peritoneal dialysis and the one or more regeneration module receives a spent dialysate containing at least one species from a subject receiving treatment and removes at least a portion of a species from the dialysate to regenerate the dialysate for recirculation of at least a portion of the regenerated dialysate to the subject receiving treatment.

5. The system of any one of claims 1 , 2 , 3 or 4 , wherein at least one sensor measures conductivity of the fluid.

6. The system of any one of claims 1 , 2 , 3 or 4 , wherein at least one sensor measures at least one characteristic of the fluid selected from the group of pH and ammonium ion.

7. A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid, comprising:
the sorbent system of claim 1 having the first sensor contacting at least a first position of the at least one material layer or a first position from the primary flow stream; and
the second sensor contacting either a second position of the at least one material layer or a second position from the primary flow stream;
wherein the first sensor and the second sensor determine the amount or concentration of at least one solute.

8. The system of claims 1 or 7 , wherein the monitoring system comprises at least two sensors.

9. The system of claims 1 or 7 , wherein the monitoring system comprises a plurality of sensors.

10. The system of claim 8 , wherein at least one of said sensors forms part of a conductivity meter.

11. The system of claim 9 , wherein at least one of said sensors forms part of a conductivity meter.

12. The system of claims 1 or 7 , wherein a plurality of sensors are configured to measure one or more solute concentrations.

13. The system of claim 10 , wherein said meter is configured to measure the conductivity of at least one solute concentration.

14. The system of claim 11 , wherein said meter is configured to measure the conductivity of at least one solute concentration.

15. The system of claims 1 or 7 , wherein the monitoring system comprises a plurality of sensors that can measure the conductivity of a plurality of separate material layers and flow streams.

16. The system of claim 1 , further comprising at least two sensing points within any one of the material layers.

17. The system of claim 1 , further comprising at least two sensing points within different material layers.

18. The system of claim 1 , wherein the plurality of material layers include one or more selected from a urease-containing material, alumina, zirconium phosphate, magnesium phosphate, zirconium oxide, and activated carbon.

19. The system of claim 18 , wherein the solute concentration of urea is measured.

20. The system of claim 19 , wherein the solute concentration of urea in the fluid entering a material layer is determined by obtaining a first measurement from the fluid before contacting a urease containing layer and a second measurement from the fluid after having contacted the urease containing layer.

21. The system of claim 20 , wherein the first and second measurements are conductivity measurements.

22. The system of claim 20 , wherein the first and second measurements are pH measurements.

23. The system of claim 18 , wherein at least one sensor is an ammonium sensor and the solute concentration of urea in the fluid is determined in part by measurement of an ammonium ion concentration in the fluid after contacting a urease containing layer.

24. The system of claim 18 , wherein a solute concentration of urea from an amount of carbon dioxide release from said urease-containing material is measured.

25. The system of claim 1 , further comprising a fluid flow path in fluid communication with the sorbent regeneration system.

26. The systems of claim 25 , further comprising a fluid flow monitor attached to said fluid flow path for determining an amount of fluid flowing through the sorbent regeneration system.

27. The system of claim 26 , wherein said fluid flow monitor is configured to calculate a mass flow rate of urea contained in the fluid stream.

28. The system of claim 27 , wherein said fluid flow monitor is configured to calculate a total amount of urea removed in a time interval.

29. The system of claim 28 , wherein the system is configured to determine what portion of the regenerative capacity of the one or more regeneration module has been consumed based on the total amount of urea removed.

30. The system of claim 29 , wherein an estimate of a conductivity meter of a subject undergoing treatment is used to estimate the Urea Reduction Ratio for the treatment.

31. The system of claim 29 wherein the system is configured to determine an amount of bicarbonate released from the sorbent regeneration system based on the total amount of urea removed.

32. The system of claim 29 , wherein the system is configured to determine a further amount, if any, to be infused by reconstitution system, based on a determination of an amount of bicarbonate released from a sorbent system.

33. The system of claim 1 , further comprising a multiplexer receiving signals from at least one sensor.

34. The system of claim 33 , further comprising at least one processor for processing the signals received from the multiplexer.

35. The system of claim 1 , wherein the fluid such as spent dialysate exiting a dialyzer is conveyed through the one or more regeneration module and does no

Assignees

• Medtronic Inc

Inventors

• Pudil Bryant J
• Meyer Thomas E
• Lura David B
• Gerber Martin T

Classifications

• B01J20/0292

  Phosphates of compounds other than those provided for in B01J20/048 · CPC title

• A61M1/1696 Primary

  with dialysate regeneration · CPC title

• B01D15/08

  Selective adsorption, e.g. chromatography · CPC title

• B01J47/14

  Controlling or regulating · CPC title

• A61M1/288

  Priming (priming in extracorporeal blood circuits A61M1/3643) · CPC title