Biocompatible adhesive materials and methods

Patent metadata

Field	Value
Publication number	US-9707313-B2
Application number	US-201414446805-A
Country	US
Kind code	B2
Filing date	Jul 30, 2014
Priority date	Apr 13, 2011
Publication date	Jul 18, 2017
Grant date	Jul 18, 2017

Abstract

Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.

First claim

We claim:

1. A kit for making an adhesive comprising:
a first part which includes a first solution comprising a polymer component, wherein the polymer component comprises a polymer having one or more aldehyde groups; and
a second part which includes a second solution comprising a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups, wherein less than 75% of the surface groups comprise at least one primary or secondary amine.

2. The kit of claim 1 , further comprising a syringe, wherein the first and second solutions are stored in the syringe.

3. The kit of claim 2 , wherein the syringe comprises separate reservoirs for the first solution and second solution.

4. The kit of claim 3 , wherein the syringe comprises a mixing tip.

5. The kit of claim 1 , further comprising at least two reservoirs with different concentrations of the first solution.

6. The kit of claim 1 , further comprising at least two reservoirs with different concentrations of the second solution.

7. The kit of claim 1 , further comprising instructions for selecting an appropriate concentration of at least one of the first solution or second solution to compensate for the characteristics of one or more biological tissues.

8. The kit of claim 1 , wherein the dendrimer component, polymer component, or both components, comprise a drug.

9. The kit of claim 1 , wherein the dendrimer component, polymer component, or both components, comprise stem cells or other cells.

10. A drug delivery composition comprising:
a polymer component, wherein the polymer component comprises a polymer having one or more aldehyde groups;
a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups, wherein less than 75% of the surface groups comprise at least one primary or secondary amine; and
at least one drug combined with at least one of the polymer component and dendrimer component.

11. The composition of claim 10 , wherein the polymer and dendrimer components are in a combination effective for the composition to adhere to a biological tissue.

Assignees

• Massachusetts Inst Technology

Inventors

• Artzi Natalie
• Edelman Elazer R
• Jorge Nuria Oliva
• Solanes Maria Carcole

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61L24/0005

  Ingredients of undetermined constitution or reaction products thereof · CPC title

• A61M5/19

  having more than one chamber {, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly (surgical glue applicators A61B17/00491)} · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61L24/0015

  Medicaments; Biocides · CPC title