Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound therapy

Patent metadata

Field	Value
Publication number	US-9700742-B2
Application number	US-201414516442-A
Country	US
Kind code	B2
Filing date	Oct 16, 2014
Priority date	Apr 12, 2010
Publication date	Jul 11, 2017
Grant date	Jul 11, 2017

Abstract

Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.

First claim

We claim:

1. A high intensity focused ultrasound (HIFU) system for treating tissue, the HIFU system comprising: an ultrasound source having a frequency range between approximately 0.5 MHz and approximately 20 MHz, the ultrasound source being configured to deliver a peak positive pressure between approximately 10 MPa and approximately 100 MPa, wherein the ultrasound source is configured to generate shock waves proximate to a target site in the tissue and distinct from shock waves resulting from cavitation; a function generator operably coupled to the ultrasound source, the function generator being configured to generate a pulsing protocol delivered by the ultrasound source to the target site of tissue, wherein the pulsing protocol comprises at least one of ultrasound source frequency, peak positive pressure, pulse length, shock wave amplitude, pulse repetition frequency, and duty cycle; a monitoring system configured to distinguish boiling from cavitation in the tissue; and a controller operably coupled to the ultrasound source and the function generator, wherein the controller is configured to adjust the pulsing protocol during treatment in response to feedback from the monitoring system to induce boiling during each pulse with substantially no thermal damage to the tissue at the target site and surrounding the target site.

2. The HIFU system of claim 1 wherein the monitoring system comprises an imaging device configured to detect hyperechoic regions in the tissue.

3. The HIFU system of claim 1 wherein the monitoring system comprises a voltage probe configured to detect fluctuations in drive voltage of the ultrasound source.

4. The HIFU system of claim 1 wherein the monitoring system comprises a passive cavitation detector (PCD) having a focus aligned with a focus of the ultrasound source, the focus of the PCD being configured to detect changes in acoustic signals related to boiling.

5. The HIFU system of claim 1 wherein the monitoring system comprises a magnetic resonance imaging system configured to detect temperature and boiling activity at the target site.

6. The HIFU system of claim 1 wherein the monitoring system comprises an ultrasound imaging device configured to send and receive signals that detect the presence of bubbles in the tissue.

7. The HIFU system of claim 1 wherein the monitoring system is configured to detect the presence of boiling bubbles in the tissue.

8. The HIFU system of claim 1 wherein the pulsing protocol comprises peak positive pressure and the peak positive pressure is a result of nonlinear propagation of HIFU waves, resulting in the shock waves proximate to the target site in the tissue that at least substantially emulsify the tissue at the target site.

9. A method for treating tissue with high intensity focused ultrasound (HIFU), the method comprising: generating, from an ultrasound source, HIFU waves having a frequency range between approximately 0.5 MHz and approximately 20 MHz and a peak positive pressure between approximately 10 MPa and approximately 100 MPa; and generating a pulsing protocol used by the ultrasound source to apply the HIFU waves to a target site of tissue, wherein the pulsing protocol defines at least one of ultrasound source frequency, peak positive pressure, pulse length, shock wave amplitude, pulse repetition frequency, and duty cycle, wherein the generated HIFU waves are configured to generate shock waves in tissue at the target site distinct from shock waves resulting from cavitation; wherein the shock waves induce boiling in the tissue at the target site, and wherein the induced boiling mechanically damages the tissue at the target site with substantially no thermal damage to the tissue.

10. The method of claim 9 wherein the peak positive pressure is a result of nonlinear propagation of the HIFU waves resulting in the shock waves in the tissue at the target site that at least substantially emulsify the tissue at the target site.

11. The method of claim 9 , further comprising monitoring to distinguish boiling from cavitation in the tissue at the target site.

12. The method of claim 11 , wherein the monitoring comprises detecting the presence of boiling bubbles in the tissue.

13. The method of claim 11 wherein the monitoring comprises sending and receiving signals, using an ultrasound imaging device, that detect the presence of bubbles in the tissue.

14. The method of claim 11 wherein the monitoring comprises detecting hyperechoic regions in images of the tissue.

15. The method of claim 11 wherein the monitoring comprises detecting, using a voltage probe, fluctuations in drive voltage of the ultrasound source.

16. The method of claim 11 wherein the monitoring comprises aligning a focus of a passive cavitation detector with a focus of the ultrasound source to detect changes in acoustic signals related to boiling.

17. The method of claim 11 wherein the monitoring comprises detecting temperature and boiling activity at the target site using a magnetic resonance imaging system.

18. The method of claim 11 , further comprising adjusting, in response to feedback from the monitoring, the pulsing protocol during treatment, wherein the ultrasound waves generated as a result of the adjusted pulsing protocol induce boiling during each pulse.

19. A high intensity focused ultrasound (HIFU) apparatus for treating tissue, the HIFU apparatus comprising: an ultrasound source configured to deliver a peak positive pressure between approximately 10 MPa and approximately 100 MPa, wherein the ultrasound source is configured to generate shock waves proximate to a target site in the tissue and distinct from shock waves resulting from cavitation; a function generator operably coupled to the ultrasound source, the function generator being configured to generate a pulsing protocol delivered by the ultrasound source to the target site of tissue, wherein the pulsing protocol comprises at least one of ultrasound source frequency, peak positive pressure, pulse length, shock wave amplitude, pulse repetition frequency, and duty cycle; a monitoring system configured to distinguish boiling from cavitation in the tissue; and a controller operably coupled to the ultrasound source and the function generator, wherein the controller is configured to adjust the pulsing protocol during treatment in response to feedback from the monitoring system to induce boiling during each pulse with substantially no thermal damage to the tissue at the target site and surrounding the target site.

Assignees

• Univ Of Washington Through Its Center For Communication
• Univ Washington

Inventors

• Canney Michael S
• Bailey Michael R
• Crum Lawrence A
• Khokhlova Vera A
• Khokhlova Tatiana D
• Kreider Wayne
• Hwang Joo Ha
• Sapozhnikov Oleg A

Classifications

• A61B2090/374

  NMR or MRI · CPC title

• A61N7/02 Primary

  Localised ultrasound hyperthermia · CPC title

• A61B2017/00084

  Temperature · CPC title

• A61B2090/378

  using ultrasound · CPC title

• A61B2018/00005

  Cooling or heating of the probe or tissue immediately surrounding the probe · CPC title