Composition containing S-adenosyl-L-methionine with excellent storage stability

Patent metadata

Field	Value
Publication number	US-9700629-B2
Application number	US-201214238029-A
Country	US
Kind code	B2
Filing date	Jul 20, 2012
Priority date	Aug 12, 2011
Publication date	Jul 11, 2017
Grant date	Jul 11, 2017

Abstract

The present invention relates to a composition including S-adenosyl-L-methionine; and at least one kind of additive selected from carboxymethylcellulose, hydroxypropylcellulose, soybean polysaccharide, casein sodium, and zein, in which S-adenosyl-L-methionine is extracted from S-adenosyl-L-methionine-containing cells obtained by culturing a microorganism having an ability to produce SAMe, and the content of the additive in the composition falls within the range of 0.05 to 15 times by mass of S-adenosyl-L-methionine in the composition. The present invention provides a composition containing a high concentration of S-adenosyl-L-methionine, which is useful as a water-soluble physiologically active substance, and being excellent in storage stability and bioabsorbability. The present invention also relates to a molded article formed by using the composition and a method of producing the composition.

First claim

What is claimed is:

1. A composition comprising, in admixture:
a microorganism cell extract comprising S-adenosyl-L-methionine; and
at least one additive selected from the group consisting of soybean polysaccharide, casein sodium, and zein,
wherein:
the microorganism cell extract comprising S-adenosyl-L-methionine is extracted from an S-adenosyl-L-methionine-containing cell obtained by culturing a microorganism having an ability to produce S-adenosl-L-methionine;
a content of the S-adenosyl-L-methionine in the composition is in a range of 3% to 18.8% by mass, based on the dry mass of the composition;
a content of the additive in the composition is in a range of 0.05 to 15 times by mass of the S-adenosyl-L-methionine in the composition; and
the admixture of the microorganism cell extract comprising S-adenosyl-L-methionine and the at least one additive is produced by mixing the microorganism cell extract comprising S-adenosyl-L-methionine and the at least one additive.

2. The composition according to claim 1 , wherein the composition is solid.

3. A molded article comprising the composition according to claim 2 .

4. The composition according to claim 1 , comprising soybean polysaccharide.

5. The composition according to claim 1 , comprising casein sodium.

6. The composition according to claim 1 , comprising zein.

7. The composition according to claim 1 , wherein the microorganism belongs to the genus Saccharomyces, Candida, Pi chia, Mucor, Rhizopus, Brevibacterium, Corynebacterium, Esherichia , or Streptomyces.

8. The composition according to claim 1 , wherein the microorganism is Saccharomyces cerevisiae .

Assignees

• Takano Kentaro
• Gayama Shinyo
• Mitsubishi Gas Chemical Co

Inventors

• Takano Kentaro
• Gayama Shinyo

Classifications

• A61P3/06

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• A61P25/28

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• A61P25/24

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• A61P25/20

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