Methods of treating cognitive impairment

Patent metadata

Field	Value
Publication number	US-9700597-B2
Application number	US-201514730485-A
Country	US
Kind code	B2
Filing date	Jun 4, 2015
Priority date	Aug 5, 2008
Publication date	Jul 11, 2017
Grant date	Jul 11, 2017

Abstract

The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (Flt3) ligand, interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), interleukin-1 (IL-1), interleukin-3 (IL-3), erythropoietin (EPO), vascular endothelial growth factor A (VEGF-A), hypoxia-inducible transcription factor (HIF-1alpha), insulin like growth factor-1 (IGF-1), tumor necrosis factor (TNF), granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), Stem Cell Factor (SCF), Darbepoetin (ARANESP), and metalloproteinases, to an animal or person in need of treatment.

First claim

We claim:

1. A method for improving cognition in a person or animal receiving or that has received chemotherapy or radiation exposure or treatment for the treatment of cancer, wherein improvements in cognition are characterized by improvements in memory, attention, concentration, and/or executive function, said method comprising administering to the person or animal that is receiving or that has received chemotherapy or radiation exposure or treatment for the treatment of cancer an effective amount of an inflammatory mediator(s), or a composition comprising said inflammatory mediator(s), wherein said inflammatory mediator is granulocyte/macrophage colony-stimulating factor (GM-CSF), or granulocyte colony-stimulating factor (G-CSF), or an analog of said inflammatory mediator, wherein the analog of GM-CSF is sargramostim and wherein the analog of G-CSF is filgrastim or pegfilgrastim, and wherein the cognition of the person or animal after administration of said inflammatory mediator or composition is improved relative to the cognition of the person or animal prior to administration of said inflammatory mediator or composition.

2. The method of claim 1 , wherein said inflammatory mediator is administered intracranially.

3. The method of claim 1 , wherein said inflammatory mediator is administered by intracranial infusion.

4. The method of claim 1 , wherein said inflammatory mediator is administered to a non-neural cell or tissue.

5. The method of claim 1 , wherein said method further comprises evaluating the person or animal for cognitive function prior to treatment.

6. The method of claim 1 , wherein said composition comprises a pharmaceutically acceptable carrier, diluent, or solute.

7. The method of claim 1 , wherein said method further comprises administering Darbepoetin and/or erythropoietin (EPO) to the person or animal.

8. The method of claim 1 , where said GM-CSF is human GM-CSF.

9. The method of claim 1 , wherein the cancer is multiple myeloma or non-Hodgkin's lymphoma.

10. The method of claim 1 , wherein the person or animal received hematopoietic cell transplantation (HCT).

11. The method of claim 1 , wherein said inflammatory mediator is administered orally, intravenously, intramuscularly, intraperitoneally, subcutaneously, or intranasally.

12. The method of claim 1 , wherein the cancer is acute myelogenous leukemia, myelodysplastic syndrome, acute lymphoblastic leukemia, breast carcinoma, chronic lymphocytic leukemia, chronic myelogenous leukemia, myeloproliferative neoplasm, Hodgkin's lymphoma, or aplastic anemia.

13. The method of claim 1 , where said G-CSF is human G-CSF.

Assignees

• Univ South Florida
• H Lee Moffitt Cancer Ct & Res

Inventors

• Potter Huntington
• Boyd Timothy
• Jim Heather Sevey Lawrence

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A01K2217/052

  inducing gain of function · CPC title

• A01K2227/105

  Murine · CPC title

• A01K2267/0312

  Animal model for Alzheimer's disease · CPC title