Anti-cancer agent

Patent metadata

Field	Value
Publication number	US-9700572-B2
Application number	US-201414494637-A
Country	US
Kind code	B2
Filing date	Sep 24, 2014
Priority date	Mar 26, 2012
Publication date	Jul 11, 2017
Grant date	Jul 11, 2017

Abstract

The present invention is intended to provide a novel anticancer agent which is effective to a cancer. After administering an agent prepared using burdock fruit extract to a pancreas cancer patient so that a dose of arctigenin was 100 mg or more per day, the tumor reducing effect was observed, and, in addition, lowering of tumor markers was confirmed. The present invention provides an anticancer agent containing arctigenin, wherein a dose of the arctigenin is 100 mg or more per day. In addition, the present invention provides the anticancer agent containing arctigenin and arctiin at a weight ratio of arctigenin/arctiin=0.7 to 1.3.

First claim

What is claimed is:

1. A method of treating pancreatic cancer comprising administering to a human patient in need thereof, a dose of arctigenin of at least 148.5 mg per day.

2. The method of claim 1 , further comprising administering to said patient a dose of arctiin of at least 171.25 mg per day.

3. The method of claim 1 or claim 2 , wherein said pancreatic cancer is refractory to treatment with gemcitabine.

4. The method of claim 2 , wherein said method of treating pancreatic cancer comprises reducing recurrences and metastases of pancreatic cancer which occur after cancer treatment.

5. A method of inhibiting pancreatic cancer stem cells comprising administering to said human patient in need thereof, a composition comprising arctigenin at a dose of at least 148.5 mg or more per day.

6. A method for reducing recurrences and metastases of pancreatic cancer which occur after cancer treatment in a human patient, comprising administering a composition containing arctigenin in a dose of at least 148.5 mg per day to said patient.

Assignees

• Kracie Pharma Ltd
• Nat Cancer Ct
• Nat Univ Corp Univ Of Toyama

Inventors

• Esumi Hiroyasu
• Ikeda Masafumi
• Miyoshi Chika
• Kadota Shigetoshi
• Okubo Toshiki
• Yomoda Satoshi
• Fuse Takafumi
• Kawashima Takanori
• Chiba Shigeki

Classifications

• A61K31/365

  Lactones · CPC title

• A61K31/341 Primary

  not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine · CPC title

• A61K36/28

  Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea · CPC title

• A61K31/7048 Primary

  having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin} · CPC title

• A61K31/7034

  attached to a carbocyclic compound, e.g. phloridzin · CPC title