Detection system for detecting magnetic objects in the human organism

Patent metadata

Field	Value
Publication number	US-9696279-B2
Application number	US-201214367682-A
Country	US
Kind code	B2
Filing date	Jan 9, 2012
Priority date	Dec 21, 2011
Publication date	Jul 4, 2017
Grant date	Jul 4, 2017

Abstract

The subject matter of the invention is a detector system for detecting magnetic bodies in the human organism, which comprises at least two sensor assemblies, wherein each sensor assembly has one, two or three anisotropic magnetic resistance sensors, of which the axes of weak magnetization point in different directions in pairs, and each sensor assembly has a spacing of 0.5 to 50 cm from the sensor assembly or the other sensor assemblies, and at least two sensor assemblies are tilted at an angle of 0 to 45° with respect to one another, and in addition a method for detecting the magnetic flux produced by a magnetic body in the human organism, and the use of the detector system according to the invention for detecting swallowed magnetic bodies and the disintegration of the same in the digestive system.

First claim

The invention claimed is:

1. A detector system comprising
at least two sensor assemblies, wherein each sensor assembly has two or three anisotropic magnetic resistance (AMR) sensors, wherein the axes of weak magnetization of the sensors point in different directions in pairs, and each sensor assembly has a spacing of 0.5 to 50 cm from another sensor assembly, and
at least two of said sensor assemblies are tilted at an angle of 0 to 45° with respect to one another,
wherein said detector system is capable of detecting magnetic bodies in the human organism.

2. The detector system as claimed in claim 1 , wherein said detector system further comprises a set reset strap, an offset strap, and wherein at least one AMR sensor has four barber pole elements, wherein said barber pole elements are connected together to form a Wheatstone bridge or a Wheatstone bridge equivalent circuit.

3. The detector system as claimed in claim 1 wherein the magnetic body is a capsule or capsule with function, wherein the function is chosen from diagnostic and/or pharmacological form, and said magnetic body is swallowed by the human organism, and said magnetic body has at least one ferromagnetic component.

4. A method for detecting the magnetic flux density produced by the magnetic body in the human organism wherein said method comprises
(a) placing the detector system of claim 1 in proximity to the human organism,
(b) connecting a set and reset pulse to each AMR sensor at least once,
(c) amplifying the signals from each AMR sensor via suitable signal conditioning and via at least one low pass filter,
(d) determining the difference between the magnitudes of the vectors of the magnetic flux densities from each sensor assembly, and/or
determining the angle Φ between the vectors from the measured signals from the AMR sensors.

5. The method as claimed in claim 4 , wherein the contribution of each AMR sensor or the measured signal obtained in (d) is filtered by a median filter.

6. The method as claimed in claim 4 , wherein in (c) at least one low pass filter has a cut-off frequency selected from the group consisting of 0.1-0.99 mHz, 1 mHz-0.99 Hz, 1 Hz-9.99 Hz, and 10 Hz-1 kHz, or a combination of low pass filters having at least two different cut-off frequencies selected from said cut-off frequency group are used.

7. A method for detecting the oral administration form and for determining the time or times of the disintegration of the magnetic component in the digestive tract comprising detecting the magnetic flux density produced by the magnetic body in the human organism as in the method in claim 4 .

8. The method as claimed in claim 7 , wherein said measured signals are stored in a data storage device.

9. The method as claimed in claim 7 wherein said method is performed in a data management network.

10. The method as claimed in claim 7 , wherein said method is performed in therapy, diagnosis and/or nutrition.

11. The method as claimed in claim 8 , wherein the information on the data storage device is transmitted to a receiving device upon the receipt of a requested signal.

12. The method as claimed in claim 11 wherein said method is performed in a data management network.

13. The method as claimed in claim 11 where said method is performed in therapy, diagnosis and/or nutrition.

Assignees

• Hartwig Benedikt
• Niepoth Peter
• Junginger Steffen
• Stiller Hans-Joachim
• Windhab Norbert
• Geipel Gerhard
• Evonik Roehm Gmbh

Inventors

• Hartwig Benedikt
• Niepoth Peter
• Junginger Steffen
• Stiller Hans-Joachim
• Windhab Norbert
• Geipel Gerhard

Classifications

• A61B5/073

  Intestinal transmitters · CPC title

• G01N27/72 Primary

  by investigating magnetic variables · CPC title

• G01R33/028

  Electrodynamic magnetometers · CPC title

• A61B5/0515

  Magnetic particle imaging · CPC title

• A61B1/041 Primary

  Capsule endoscopes for imaging · CPC title