US9695130B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9695130-B2 |
| Application number | US-201515116861-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 6, 2015 |
| Priority date | Feb 6, 2014 |
| Publication date | Jul 4, 2017 |
| Grant date | Jul 4, 2017 |
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An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.
Opening claim text (preview).
The invention claimed is: 1. A production method of rosuvastatin calcium, comprising (B) a step of converting a compound represented by the following formula (12): wherein M is an alkali metal element, an alkaline earth metal element or hydrogen, to a compound represented by the following formula (13): 2. The production method according to claim 1 , comprising, prior to said step (B), (Aa) a step of converting a mixture of a compound represented by the following formula (14): wherein R is a primary alkyl group having 1-8 carbon atoms or a secondary alkyl group having 3-6 carbon atoms, and a compound represented by the following formula (15): wherein R is as defined above, to a mixture of a compound represented by the following formula (16): wherein M is an alkali metal element, an alkaline earth metal element or hydrogen, and a compound represented by said formula (12), by hydrolyzing same in the presence of a base. 3. A purification method of rosuvastatin calcium comprising a compound represented by the following formula (12): wherein M is an alkali metal element, an alkaline earth metal element or hydrogen, comprising (B) a step of converting the compound represented by the formula (12) to a compound represented by the following formula (13): 4. Rosuvastatin calcium comprising not less than 1 ppm and not more than 1000 ppm of a compound represented by the following formula (13):
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