Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof

Patent metadata

Field	Value
Publication number	US-9695129-B2
Application number	US-201615148168-A
Country	US
Kind code	B2
Filing date	May 6, 2016
Priority date	Apr 20, 2012
Publication date	Jul 4, 2017
Grant date	Jul 4, 2017

Abstract

The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

First claim

What is claimed is:

1. A compound of the formula:

wherein:
R 6 is hydrogen;
R 7 is (C 4 -C 6 )— alkyl, (C 2 -C 5 )— alkenyl, or (C 2 -C 5 )— alkynyl;
R 8 is hydrogen, fluorine or chlorine; and
R 9 is hydrogen.

2. A compound according to claim 1 , wherein R 7 is hexyl.

3. A compound according to claim 1 , wherein R 7 is pentyne.

4. A compound according to claim 1 that is 6-chloro-5-hexyl-2-methylthiobenzimidazole.

5. A composition for treating helminth infestation comprising an anthelmintically effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier.

6. A composition for treating helminth infestation according to claim 5 wherein the composition is combined with an additional active agent.

7. A composition for treating helminth infestation according to claim 6 wherein the additional active agent is a macrocyclic lactone.

8. A composition for treating helminth infestation according to claim 7 wherein the macrocyclic lactone is selected from the group consisting of abamectin, dimadectin, doramectin, emamectin, eprinomectin, ivermectin, latidectin, lepimectin, selamectin or ML-1,694,554.

9. A composition for treating helminth infestation according to claim 6 wherein the additional active agent is verapamil.

10. A method for treating helminth infestation comprising administration of an anthelmintically effective amount of the compound of claim 1 to an animal in need thereof.

11. A method according to claim 10 in which the helminths are trematodes.

12. A method according to claim 11 in which the helminths are Fasciola hepatica.

Assignees

• Merial Inc

Inventors

• Meng Charles Q

Classifications

• A61P33/10

  Anthelmintics · CPC title

• A61P33/00

  Antiparasitic agents · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P33/12

  Schistosomicides · CPC title

• A61P33/14

  Ectoparasiticides, e.g. scabicides · CPC title