System, method and equipment for implementing temporary diamagnetic propulsive focusing effect with transient applied magnetic field pulses

Patent metadata

Field	Value
Publication number	US-9694196-B2
Application number	US-201414182488-A
Country	US
Kind code	B2
Filing date	Feb 18, 2014
Priority date	Apr 10, 2013
Publication date	Jul 4, 2017
Grant date	Jul 4, 2017

Abstract

An apparatus and method are utilized to transiently implement diamagnetic behavior in both permanently and transiently magnetized particles.

First claim

What is claimed is:

1. A method of eliciting diamagnetic behavior in at least one ferromagnetic, paramagnetic, super-paramagnetic, or other magnetizable or magnetic particles, the method comprising:
applying at least one transient magnetic gradient field to at least one particle,
wherein the at least one particle has been polarized and/or oriented through the application of a magnetic field in a direction that is opposing the direction of the transient magnetic gradient field, and
wherein the particle is translated in space as a result of the force applied by the at least one transient magnetic gradient field.

2. The method of claim 1 , wherein onset and duration of application of the at least one transient magnetic gradient field is less than the time required for the at least one particle to completely depolarize.

3. The method of claim 1 , wherein onset and duration of application of the at least one transient magnetic gradient field is less than the time required for the at least one particle to re-orient itself.

4. The method of claim 1 , wherein the at least one particle travels towards the direction of decreasing magnetic gradient strength.

5. The method of claim 1 , wherein the effect of repeated application of diamagnetic behavior is used to concentrate particles in space.

6. The method of claim 1 , wherein the at least one particle is loaded with a chemical.

7. The method of claim 1 , wherein the at least one particle delivers therapy or potentiates therapy.

8. The method of claim 1 , wherein intervening magnetic pulses provide imaging guidance for particle motion.

9. The method of claim 1 , wherein degaussing magnetic pulses de-clump assemblies of particles.

10. An apparatus of at least one electromagnetic coil and/or permanent magnet controlled by a computer and/or electronic system, in which the apparatus provides at least one transient magnetic gradient field to at least one ferromagnetic, paramagnetic, super-paramagnetic, or other magnetizable or magnetic particle, where the at least one particle has been polarized and/or oriented through the application of a magnetic field in a direction that is opposing the direction of the transient magnetic gradient field, and wherein the particle is translated in space as a result of the force applied by the at least one transient magnetic gradient field.

11. The apparatus of claim 10 , wherein the onset and duration of application of the at least one transient magnetic gradient field is less than the time required for the at least one particle to completely depolarize.

12. The apparatus of claim 10 , wherein the onset and duration of application of the at least pulsed magnetic gradient field is less than the time required for the at least one particle to re-orient itself.

13. The apparatus of claim 10 , wherein the at least one particle travels towards the direction of decreasing magnetic gradient strength.

14. The apparatus of claim 10 , wherein the effect of repeated use of the apparatus concentrates particles in space.

15. The apparatus of claim 10 , wherein the at least one particle is loaded with a chemical.

16. The apparatus of claim 10 , wherein the at least one particle delivers therapy or potentiates therapy.

17. The apparatus of claim 10 , wherein intervening magnetic pulses provide imaging guidance for particle motion.

18. The apparatus of claim 10 , wherein at least one electromagnetic coil is cooled in order to increase magnetic field strength.

19. The apparatus of claim 10 , wherein the apparatus delivers degaussing magnetic pulses in order to de-clump assemblies of particles.

Assignees

• Weinberg Medical Physics Llc
• Weinberg Medical Physics Inc

Inventors

• Weinberg Irving N
• Nacev Aleksandar Nelson
• Stepanov Pavel

Classifications

• A61M37/00

  Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title

• A61N2/02 Primary

  using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) · CPC title

• A61N2005/1098

  Enhancing the effect of the particle by an injected agent or implanted device · CPC title

• G01R33/1276 Primary

  of magnetic particles, e.g. imaging of magnetic nanoparticles (G01R33/1269 takes precedence) · CPC title

• A61K41/0028

  Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds · CPC title