Biodisintegrable medical devices

Patent metadata

Field	Value
Publication number	US-9694110-B2
Application number	US-201314063384-A
Country	US
Kind code	B2
Filing date	Oct 25, 2013
Priority date	Dec 4, 2007
Publication date	Jul 4, 2017
Grant date	Jul 4, 2017

Abstract

The present disclosure relates to medical devices which contain one or more polymeric regions that are at least partially biodisintegrable in bodily fluid. These devices may be implanted or inserted into a subject for treatment of various diseases, disorders and conditions. The present disclosure further provides methods of slowing and/or accelerating the dissolution of such medical devices by administering a composition which alters the pH of the subject's urine.

First claim

The invention claimed is:

1. A method of treating a subject, comprising: administering to the subject a composition that alters the pH of the subject's urine, said subject having inserted or implanted therein a urological medical device that comprises a first polymeric portion comprising a dissolvable polymer and a second polymeric portion comprising a non-dissolvable polymer, wherein the composition accelerates the dissolution of said dissolvable polymer.

2. The method of claim 1 , wherein said dissolvable polymer comprises acidic groups and wherein the composition increases the pH thereby accelerating the dissolution of said dissolvable polymer.

3. The method of claim 1 , wherein said dissolvable polymer comprises acidic groups and wherein the composition decreases the pH thereby slowing the dissolution of said dissolvable polymer.

4. The method of claim 1 , wherein said dissolvable polymer comprises basic groups and wherein the composition decreases the pH thereby accelerating the dissolution of said dissolvable polymer.

5. The method of claim 1 , wherein said dissolvable polymer comprises basic groups and wherein the composition increases the pH thereby slowing the dissolution of said dissolvable polymer.

6. The method of claim 1 , wherein said urological medical device is a ureteral stent.

7. The method of claim 1 , wherein the first polymeric portion of the urological medical device is disposed within a bladder of the subject.

8. The method of claim 1 , wherein the second polymeric portion of the urological medical device is disposed within a ureter or kidney of the subject.

9. The method of claim 1 , wherein the first polymeric portion completely dissolves following administration of said composition.

10. The method of claim 1 , wherein the first polymeric portion partially dissolves following administration of said composition.

11. A method of treating a subject, comprising: administering to the subject a composition that alters the pH of the subject's urine, said subject having inserted or implanted therein a urological medical device that comprises a first polymeric portion comprising a dissolvable polymer and a second polymeric portion comprising a partially dissolvable polymer, wherein the composition accelerates the dissolution of said dissolvable and partially dissolvable polymers.

12. The method of claim 11 , wherein the dissolvable polymer of the first polymeric portion dissolves more slowly than the partially dissolvable polymer of the second polymeric portion.

13. The method of claim 11 , wherein said dissolvable and partially dissolvable polymers comprise acidic groups and wherein the composition increases the pH thereby accelerating the dissolution of said dissolvable and partially dissolvable polymers.

14. The method of claim 11 , wherein said urological medical device is a ureteral stent.

15. The method of claim 11 , wherein the first polymeric portion of the urological medical device is disposed within a bladder of the subject.

16. The method of claim 11 , wherein the second polymeric portion of the urological medical device is disposed within a ureter or kidney of the subject.

17. The method of claim 11 , wherein the first polymeric portion completely dissolves following administration of said composition.

18. The method of claim 11 , wherein the first polymeric portion partially dissolves following administration of said composition.

Assignees

• Boston Scient Scimed Inc

Inventors

• Sheth Piyush

Classifications

• A61L27/58 Primary

  Materials at least partially resorbable by the body · CPC title

• A61F2/94

  Stents retaining their form, i.e. not being deformable, after placement in the predetermined place · CPC title

• A61L31/041 Primary

  Mixtures of macromolecular compounds · CPC title

• A61P13/02

  of urine or of the urinary tract, e.g. urine acidifiers · CPC title

• A61F2/04

  Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95) · CPC title