Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods

Patent metadata

Field	Value
Publication number	US-9694106-B2
Application number	US-201213545235-A
Country	US
Kind code	B2
Filing date	Jul 10, 2012
Priority date	Jul 11, 2011
Publication date	Jul 4, 2017
Grant date	Jul 4, 2017

Abstract

Cosmetic threads for reducing wrinkle size include at least one synthetic collagen fiber that wells after placement under the skin.

First claim

That which is claimed:

1. A cosmetic treatment kit, comprising:
a plurality of discrete, separate threads of different diameters sized and configured for treating different size facial wrinkles, each thread is a single synthetic, elongate, continuous length collagen fiber in a dry or partially hydrated state, wherein the at least one synthetic, elongate, continuous length collagen fiber of each thread is configured to swell in situ in cross-sectional size at least about 30% after placement when fully hydrated, wherein, when fully hydrated, the discrete separate threads each have a resilient compressible configuration to thereby rebound after touch compression mimicking natural skin;
a sterile package holding the plurality of discrete separate threads therein; and a correlation reference/table on or in the kit, wherein the correlation reference/table provides a size of a defect, void or wrinkle to a recommended thread size to thereby facilitate a clinician's selection of a proper size thread for a treatment site.

2. The kit of claim 1 , wherein the kit comprises at least one needle sized and configured to insert a respective thread into tissue associated with a wrinkle, and wherein the respective threads are configured to swell when fully hydrated so that the outer layer of skin over the wrinkle is level with adjacent skin on each side of the wrinkle.

3. The kit of claim 1 , wherein the threads are degradable or resorbable in vivo.

4. The kit of claim 1 , wherein the at least one synthetic, elongate, continuous length collagen fiber of respective threads is a single synthetic collagen fiber and is un-cross-linked.

5. The kit of claim 1 , wherein the at least one synthetic, elongate, continuous length collagen fiber of respective threads is a single synthetic collagen fiber and is cross-linked.

6. The kit of claim 1 , wherein the threads are non load bearing, and wherein the threads comprise one or more of the following:
a collagen promoter, antioxidant, extracellular matrix macromolecules, and an anti-inflammatory agent.

7. The kit of claim 1 , wherein the synthetic, elongate, continuous length collagen fiber body of the threads are crosslinked with carbodiimide.

8. The kit of claim 1 , wherein at least some of the threads comprise gelatin in an amount between about 5-40% per fully hydrated volume that occurs after placement in tissue.

9. A cosmetic treatment kit, comprising:
a plurality of single-fiber threads of different diameters sized and configured to treat different size facial wrinkles, wherein the single fiber threads each are a single synthetic, elongate, continuous length collagen fiber body in a dry or partially hydrated state, wherein the single fiber threads are configured to swell in situ in cross-sectional size at least 30% after placement in tissue and when fully hydrated so that the outer layer of skin over the wrinkle is level with adjacent skin on each side of the wrinkle, and wherein the single-fiber threads each have a resilient compressible configuration when fully hydrated to thereby rebound after touch compression mimicking natural skin;
a package holding the plurality of single-fiber threads in a sterile condition for surgical use; and a correlation reference/table in, on or appended to the kit, wherein the correlation reference/table provides a size of a defect, void or wrinkle to a recommended thread size to thereby facilitate a clinician's selection of a proper size thread for a treatment site.

10. The kit of claim 9 , wherein the plurality of single fiber threads with the single synthetic, elongate, continuous length collagen fiber body are crosslinked with carbodiimide.

11. The kit of claim 9 , wherein the plurality of the single-fiber threads comprise cytokines and/or growth factors.

12. The kit of claim 9 , wherein the plurality of the single-fiber threads comprise antioxidants.

13. The kit of claim 9 , wherein the plurality of the single-fiber threads comprise extracellular matrix macromolecules.

14. The kit of claim 9 , wherein the plurality of the single-fiber threads comprise an anti-inflammatory agent.

15. The kit of claim 9 , wherein at least some of the threads comprise gelatin in an amount between about 5-40% per fully hydrated volume.

16. A cosmetic treatment kit, comprising:
a plurality of implantable cosmetic threads of different outer diameters, each cosmetic thread of the plurality of implantable cosmetic threads is a single synthetic, elongate, continuous length collagen fiber in a dry or partially hydrated state, wherein the plurality of cosmetic threads are sized to treat different size facial wrinkles, wherein the cosmetic threads swell in situ in cross-sectional size at least 30% after placement in tissue and when fully hydrated, wherein the cosmetic threads have a resilient compressible configuration when fully hydrated to thereby rebound after touch compression mimicking natural skin, and wherein at least some of the threads comprise gelatin in a range of 5-40% per volume when fully hydrated; and
a package holding the plurality of implantable cosmetic threads in a sterile condition for surgical use.

17. A cosmetic treatment kit, comprising:
a plurality of implantable cosmetic threads of different outer diameters, each cosmetic thread of the plurality of implantable cosmetic threads comprising at least one synthetic, elongate, continuous length collagen fiber in a dry or partially hydrated state, wherein the cosmetic threads are sized to treat different size facial wrinkles, wherein the cosmetic threads swell in situ in cross-sectional size at least 30% after placement in tissue and when fully hydrated, and wherein the cosmetic threads have a resilient compressible configuration when fully hydrated to thereby rebound after touch compression mimicking natural skin; and
a package holding the plurality of implantable cosmetic threads in a sterile condition for surgical use, wherein at least some of the threads are a single synthetic, elongate continuous length collagen fiber.

Assignees

• Brown Rebeccah
• Koob Thomas J
• Mimedx Group Inc

Inventors

• Brown Rebeccah
• Koob Thomas J

Classifications

• A61B17/06166

  Sutures (suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M) · CPC title

• A61L27/24

  Collagen · CPC title

• A61B2017/00792

  Plastic surgery · CPC title

• A61B17/0057

  Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect (sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009) · CPC title

• A61B2017/00004

  (bio)absorbable, (bio)resorbable or resorptive · CPC title