Enzymatic wound debriding compositions with enhanced enzymatic activity

Patent metadata

Field	Value
Publication number	US-9694100-B2
Application number	US-201013514945-A
Country	US
Kind code	B2
Filing date	Dec 8, 2010
Priority date	Dec 8, 2009
Publication date	Jul 4, 2017
Grant date	Jul 4, 2017

Abstract

The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.

First claim

The invention claimed is:

1. An anhydrous enzymatic wound debriding composition comprising:
(a) a hydrophilic dispersed phase comprising PEG 400 and collagenase; and
(b) a hydrophobic continuous phase comprising a hydrophobic base, wherein the hydrophilic dispersed phase is dispersed in the hydrophobic continuous phase;
wherein the amount of PEG 400 is 10-30% w/w of the composition,
wherein the composition is anhydrous, and
wherein said hydrophobic base is selected from the group consisting of isoparaffin, microcrystalline wax, heavy mineral oil, light mineral oil, ozokerite, petrolatum, and paraffin.

2. The anhydrous enzymatic wound debriding composition of claim 1 , wherein the hydrophobic base is petrolatum.

3. The anhydrous enzymatic wound debriding composition of claim 1 , wherein the amount of PEG 400 is 13-27% w/w of the composition.

4. The anhydrous enzymatic wound debriding composition of claim 3 , wherein the amount of PEG 400 is 20% w/w of the composition.

5. An anhydrous enzymatic wound debriding composition comprising:
(a) a hydrophilic dispersed phase comprising PEG 600 and collagenase; and
(b) a hydrophobic continuous phase comprising a hydrophobic base, wherein the hydrophilic dispersed phase is dispersed in the hydrophobic continuous phase;
wherein the amount of PEG 600 is 20-40% w/w of the composition,
wherein the composition is anhydrous, and
wherein said hydrophobic base is selected from the group consisting of isoparaffin, microcrystalline wax, heavy mineral oil, light mineral oil, ozokerite, petrolatum, and paraffin.

6. The anhydrous enzymatic wound debriding composition of claim 5 , wherein the hydrophobic base is petrolatum.

7. The anhydrous enzymatic wound debriding composition of claim 5 , wherein the amount of PEG 600 is 23-37% w/w of the composition.

8. The anhydrous enzymatic wound debriding composition of claim 7 , wherein the amount of PEG 600 is 30% w/w of the composition.

9. An anhydrous enzymatic wound debriding composition comprising:
(a) a hydrophilic dispersed phase comprising Poloxamer 124 and collagenase; and
(b) a hydrophobic continuous phase comprising a hydrophobic base, wherein the hydrophilic dispersed phase is dispersed in the hydrophobic continuous phase;
wherein the amount of Poloxamer 124 is 20-40% w/w of the composition,
wherein the composition is anhydrous, and
wherein said hydrophobic base is selected from the group consisting of isoparaffin, microcrystalline wax, heavy mineral oil, light mineral oil, ozokerite, petrolatum, and paraffin.

10. The anhydrous enzymatic wound debriding composition of claim 9 , wherein the hydrophobic base is petrolatum.

11. The anhydrous enzymatic wound debriding composition of claim 9 , wherein the amount of Poloxamer 124 is 23-37% w/w of the composition.

12. The anhydrous enzymatic wound debriding composition of claim 11 , wherein the amount of Poloxamer 124 is 30% w/w of the composition.

13. The anhydrous enzymatic wound debriding composition of claim 1 , wherein the composition is a liquid.

14. The anhydrous enzymatic wound debriding composition of claim 1 , wherein the composition is a semi-solid.

15. The anhydrous enzymatic wound debriding composition of claim 1 , wherein the composition is sterile.

16. The anhydrous enzymatic wound debriding composition of claim 5 , wherein the composition is a liquid.

17. The anhydrous enzymatic wound debriding composition of claim 5 , wherein the composition is a semi-solid.

18. The anhydrous enzymatic wound debriding composition of claim 5 , wherein the composition is sterile.

19. The anhydrous enzymatic wound debriding composition of claim 9 , wherein the composition is a liquid.

20. The anhydrous enzymatic wound debriding composition of claim 9 , wherein the composition is a semi-solid.

21. The anhydrous enzymatic wound debriding composition of claim 9 , wherein the composition is sterile.

Assignees

• Shi Lei
• Jovanovic Aleksa
• Aust Duncan
• Smith & Nephew Inc

Inventors

• Shi Lei
• Jovanovic Aleksa
• Aust Duncan

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61L15/38

  containing enzymes · CPC title

• C12N9/00

  Enzymes; Proenzymes; Compositions thereof (preparations containing enzymes for cleaning teeth A61K8/66, A61Q11/00; medicinal preparations containing enzymes or proenzymes A61K38/43; enzyme containing detergent compositions C11D; {enzymes with nucleic acid structure, e.g. ribozymes, C12N15/113}); Processes for preparing, activating, inhibiting, separating or purifying enzymes (preparation of malt C12C1/00) · CPC title

• A61K47/10

  Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title