Dry-coated tablet

Patent metadata

Field	Value
Publication number	US-9693962-B2
Application number	US-201314405310-A
Country	US
Kind code	B2
Filing date	May 28, 2013
Priority date	Jun 5, 2012
Publication date	Jul 4, 2017
Grant date	Jul 4, 2017

Abstract

A dry-coated tablet 1 comprises an inner core 2 which contains an active component and an outer layer 3 which contains powdery solid components and coats the inner core 2 . Openings 8 c and 9 c are formed in circular surfaces 2 a and 2 b respectively of the inner core 2 , wherein each of the openings is larger than the average particle size of a component the average particle size of which is the smallest of the powdery solid components contained in the outer layer 3 , and the inner surface 3 a of the outer layer 3 penetrates in the openings 8 c and 9 c.

First claim

The invention claimed is:

1. A dry-coated tablet comprising:
an inner core comprising a first active component; and
an outer layer comprising a plurality of powdery solid components and a second active component, wherein the outer layer coats the inner core, and wherein each of the powdery solid components is a group of particles having the same chemical composition;
wherein an opening is formed in an outer surface of the inner core, the opening is larger than an average particle size of the one of the plurality of powdery solid components having the smallest average particle size contained in the outer layer, and an inner surface of the outer layer penetrates in the opening,
wherein the inner core comprises an uncoated tablet and a coating layer coating the uncoated tablet,
wherein a recess corresponding to the opening is formed in the uncoated tablet and the coating layer coats the uncoated tablet in the recess, and
wherein a depth of the recess is larger than the average particle size of the one of the components.

2. The dry-coated tablet according to claim 1 , wherein the recess is formed as a groove.

3. The dry-coated tablet according to claim 1 , wherein the recess is formed as a hole interspersed in the outer surface of the inner core.

4. The dry-coated tablet according to claim 1 , wherein the inner core has two surfaces arranged opposed to each other, and the recess is formed in at least one of the two surfaces.

5. The dry-coated tablet according to claim 1 , wherein the inner core has two surfaces arranged opposed to each other and a circumferential surface arranged between circumferential edges of the two surfaces, and the recess is formed in the circumferential surfaces.

6. A dry-coated tablet comprising:
an inner core comprising a first active component; and
an outer layer comprising a plurality of powdery solid components and a second active component, wherein the outer layer coats the inner core, and wherein each of the powdery solid components is a group of particles having the same chemical composition;
wherein an opening is formed in an outer surface of the inner core, the opening is larger than an average particle size of the one of the plurality of powdery solid components having the smallest average particle size contained in the outer layer, and an inner surface of the outer layer penetrates in the opening,
wherein the inner core comprises an uncoated tablet and a coating layer coating the uncoated tablet, and
wherein a through-hole corresponding to the opening is formed in the uncoated tablet and the coating layer coats the uncoated tablet in the through-hole.

7. The dry-coated tablet according to claim 6 , wherein the inner core has two surfaces arranged opposed to each other, and the through-hole is formed so as to connect the two surfaces.

8. The dry-coated tablet according to claim 1 , wherein the first and second active components are the same as or different from one another.

9. The dry-coated tablet according to claim 1 , wherein the second active component contained in the outer layer forms a granule together with components other than the second active component.

10. The dry-coated tablet according to claim 1 , wherein a friability of the inner core is 1% or less.

11. The dry-coated tablet according to claim 1 , wherein the friability of the uncoated tablet is 1% or less.

12. The dry-coated tablet according to claim 1 , wherein a width of the recess is greater than or equal to 0.5 mm and the depth of the recess is greater than or equal to 0.25 mm.

Assignees

• Takeda Pharmaceuticals Co
• Takeda Pharmaceutical Ltd

Inventors

• Kawano Tetsuya

Classifications

• A61K9/209

  containing drug in at least two layers or in the core and in at least one outer layer · CPC title

• A61K9/2059

  Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin · CPC title

• A61K9/2866

  Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose · CPC title

• A61K9/2013

  Organic compounds, e.g. phospholipids, fats · CPC title

• A61K9/2846

  Poly(meth)acrylates · CPC title