Lung elasticity restoring device and related methods of use and manufacture

Patent metadata

Field	Value
Publication number	US-9693853-B2
Application number	US-201514620758-A
Country	US
Kind code	B2
Filing date	Feb 12, 2015
Priority date	Feb 12, 2014
Publication date	Jul 4, 2017
Grant date	Jul 4, 2017

Abstract

A lung device for restoring lung elasticity includes fixation members and a connecting member. The fixation member includes a first radially expandable fixation member and a second radially expandable fixation member. The first radially expandable fixation member defines a first profile in an expanded state and a lumen. The second radially expandable fixation member defines a second profile in an expanded state and a lumen. The connecting member extends between and connects the first and second fixation members. The lung elasticity restoring device is capable of reversibly extendable between an inspiration configuration and an expiration configuration, may be extendable to the inspiration configuration, and biased to the expiration configuration by the connecting member.

First claim

What is claimed is:

1. A lung device configured to be deployed in an airway, the lung device comprising:
a first radially expandable fixation member having a first profile in an expanded state and defining a lumen;
a second radially expandable fixation member having a second profile in an expanded state and defining a lumen; and
a connecting member including only one band, only one cord, or only one wire, the connecting member extending between and connecting the first radially expandable fixation member and the second radially expandable fixation member, wherein the first radially expandable fixation member and the second radially expandable fixation member are connected by only the only one band, the only one cord, or the only one wire when positioned outside of a body;
the lung device being reversibly extendable between an inspiration configuration and an expiration configuration, the lung device being extendable to the inspiration configuration and biased to the expiration configuration, the lung device being biased to the expiration configuration by the connecting member,
wherein an outer surface of one or more of the first radially expandable fixation member, the second radially expandable fixation member, and the connecting member, includes a bronchodilator.

2. The lung device of claim 1 , wherein the first and second radially expandable fixation members are balloons.

3. The lung device of claim 1 , further comprising a third radially expandable fixation member having a third profile in an expanded state.

4. The lung device of claim 1 , wherein the expanded state of the first radially expandable fixation member has a greater diameter than the expanded state of the second radially expandable fixation member.

5. The lung device of claim 2 , wherein the first radially expandable fixation member and the second radially expandable fixation member each includes protrusions extending at an oblique angle from an outer surface, the protrusions configured to protrude away from the alveoli when the lung device is implanted, the protrusions configured to anchor the first radially expandable fixation member and the second radially expandable fixation member in the airway.

6. The lung device of claim 1 , wherein the second radially expandable fixation member has a first position relative to the first radially expandable fixation member when the lung device is in the inspiration configuration; and the second radially expandable fixation member has a second position relative to the first radially expandable fixation member when the lung device is in the expiration configuration, the second position of the second radially expandable fixation member being different than the first position.

7. A lung device comprising:
a first expandable member having a first profile in an expanded state, the first expandable member forming a first end of the lung device;
a second expandable member having a second profile in an expanded state, the second expandable member forming a second end of the lung device; and
a connecting member extending between and connecting the first and second expandable members, wherein the connecting member is a tubular member having at least two lumens that extend from a proximal end to a distal end of the tubular member;
the lung device being reversibly extendable between an inspiration state and an expiration state, the lung device being extendable to the inspiration state and biased to the expiration state by the connecting member,
wherein an outer surface of one or more of the first expandable member, the second expandable member, and the connecting member, includes a bronchodilator.

8. The lung device of claim 7 , wherein the tubular member includes exactly three lumens extending from the proximal end to the distal end of the tubular member, and further defines at least three side holes extending through a wall of the tubular member.

9. The lung device of claim 1 , wherein the outer surface of one or more of the first radially expandable fixation member, the second radially expandable fixation member, and the connecting member, includes a steroid.

10. The lung device of claim 9 , wherein the bronchodilator includes one or more of albuterol, levalbuteral, ipratropium tiotropium, salmeterol, formoterol, arformoterol, indacaterol, aclidinium, glycopyrronium, and darotropium, and the steroid includes one or more of bluticasone and budesonide.

11. The lung device of claim 1 , wherein one or more of the first radially expandable fixation member, the second radially expandable fixation member, and the connecting member includes a biodegradable material.

12. The lung device of claim 11 , wherein each of the first radially expandable fixation member, the second radially expandable fixation member, and the connecting member includes a biodegradable material.

13. The lung device of claim 12 , wherein the biodegradable material includes one or more of polylactic acid, polyglycolic acid (PGA), collagen, polycaprolactone, and hyaluronic acid.

14. The lung device of claim 1 , further including a valve configured to move between a fully-open state when the lung device is in the inspiration configuration and a partially-closed state when the lung device is in the expiration configuration, wherein the valve includes one or more flaps configured to extend substantially parallel to a longitudinal axis of the lung device in the fully-open state, and extend radially inward from an inner wall of the valve in the partially-closed state.

15. A lung device comprising:
a first balloon having a first profile in an expanded state, the first balloon forming a first end of the lung device;
a second balloon having a second profile in an expanded state, the second expandable member forming a second end of the lung device; and
a connecting member extending between and connecting the first and second balloons, wherein the first balloon and the second balloon are connected by only the connecting member when the lung device is positioned outside of a body, and the connecting member is a tubular member defining at least two lumens that extend from a proximal end to a distal end of the tubular member;
the lung device being reversibly extendable between an inspiration state and an expiration state, the lung device being extendable to the inspiration state and biased to the expiration state by the connecting member,
wherein an outer surface of each of the first balloon, the second balloon, and the connecting member, includes a bronchodilator and a steroid, the bronchodilator includes one or more of albuterol, levalbuteral, ipratropium tiotropium, salmeterol, formoterol, arformoterol, indacaterol, aclidinium, glycopyrronium, and darotropium, and the steroid includes one or more of bluticasone and budesonide.

16. The lung device of claim 15 , wherein each of the first balloon, the second balloon, and the connecting member includes a biodegradable material including one or more of polylactic acid, polyglycolic acid (PGA), collagen, polycaprolactone, and hyaluronic acid.

17. The lung device of claim 16 , further including a valve configured to move between a fully-open state when the lung device is in the inspiration state and a partially-closed state when the lung device is in the expiration state, wherein the valve includes one or more flaps configured to extend substantially parallel to a longitudinal axis of the lung device in the fully-open state, and extend radially inward from an inner wall of the valve in the partially-closed state.

Assignees

• Boston Scient Scimed Inc
• Boston Scient Scimed Inc

Inventors

• Clark Bryan Allen
• Schmidt Brian L
• Flanagan Aiden

Classifications

• A61F2220/0008

  Fixation appliances for connecting prostheses to the body · CPC title

• A61F2/852

  Two or more distinct overlapping stents · CPC title

• A61F2220/0075

  sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable · CPC title

• A61F2210/0014

  using shape memory or superelastic materials, e.g. nitinol · CPC title

• A61F2002/046

  Tracheae · CPC title