Method for analysis of sample and apparatus therefor

Patent metadata

Field	Value
Publication number	US-9691594-B2
Application number	US-201414890512-A
Country	US
Kind code	B2
Filing date	Jun 27, 2014
Priority date	Aug 14, 2013
Publication date	Jun 27, 2017
Grant date	Jun 27, 2017

Abstract

A thermal analysis step, a molecule ionization step and a molecular structure analysis step are executed in parallel to a temperature increasing step. In the molecule ionization step, component molecules contained in gas evolved from a sample S due to temperature increase are ionized, and in the molecular structure analysis step, any selected ion out of molecular ions obtained in the molecule ionization step is dissociated to generate fragment ions corresponding to the structural factors of the molecule, and the structure of the molecule is analyzed on the basis of the fragment ions.

First claim

The invention claimed is:

1. A method for analysis of a sample comprising:
a temperature increasing step of increasing the temperature of a sample according to a predetermined temperature increasing program;
a thermal analysis step of performing thermal analysis on the sample;
a molecule ionization step of ionizing component molecules contained in gas evolved from the sample due to the temperature increase; and
a molecular structure analysis step of dissociating any selected ion out of molecular ions obtained in the molecule ionization step to generate fragment ions corresponding to structural factors of the molecule, and analyzing the structure of the molecule on the basis of the fragment ions, wherein the thermal analysis step, the molecule ionization step and the molecular structure analysis step are executed in parallel to the temperature increasing step, wherein thermal analysis data obtained in the thermal analysis step and data obtained in the molecular structure analysis step are displayed on the same graph with temperature set as a common variable, and wherein in the thermal analysis step, a mass variation of the sample due to the temperature increase of the sample is analyzed, the mass variation is displayed on a graph, and with respect to data obtained in the molecular structure analysis step, a thermogram of each of the generated fragment ions is displayed on the same graph as the mass variation.

2. The method for analysis of a sample according to claim 1 , wherein the thermal analysis step is executed on the sample disposed in a sample chamber, the gas evolved from the sample due to the temperature increase is fed into an analysis chamber by a skimmer-type gas introducing interface, and the molecule ionization step and the molecular structure analysis step are executed in the analysis chamber.

3. The method for analysis of a sample according to claim 2 , wherein the molecule ionization step and the molecular structure analysis step are executed by using an ion trap mass spectrometry instrument, and in the molecular structure analysis step, any selected ion out of molecular ions obtained in the molecule ionization step is captured, the captured ion is dissociated to generate fragment ions corresponding to the structural factors of the molecule, and the structure of the molecule is analyzed on the basis of the fragment ions.

4. The method for analysis of a sample according to claim 3 , wherein in the molecule ionization step, component molecules contained in the gas evolved from the sample are irradiated with light to ionize the molecules.

5. A method for analysis of a sample comprising:
a temperature increasing step of increasing temperature of a sample according to a predetermined temperature increasing program;
a thermal analysis step of performing thermal analysis on the sample;
a molecule ionization step of ionizing component molecules contained in gas evolved from the sample due to the temperature increase of the sample; and
a molecular structure analysis step of dissociating any selected ion out of molecular ions obtained in the molecule ionization step to generate fragment ions corresponding to structural factors of the molecule, and analyzing the structure of the molecule on the basis of the fragment ions,
wherein the thermal analysis step is executed on the sample disposed in a sample chamber, the gas evolved from the sample due to the temperature increase is fed into an analysis chamber by a skimmer-type gas introducing interface, and the molecule ionization step and the molecular structure analysis step are executed in the analysis chamber,
wherein the molecule ionization step and the molecular structure analysis step are executed by using an ion trap mass spectrometry instrument,
wherein in the molecule ionization step, component molecules contained in the gas evolved from the sample are irradiated with light to ionize the molecules,
wherein in the molecular structure analysis step, any selected ion out of molecular ions obtained in the molecule ionization step is captured, the captured ion is dissociated to generate fragment ions corresponding to the structural factors of the molecule, and the structure of the molecule is analyzed on the basis of the fragment ions,
wherein the thermal analysis step, the molecule ionization step and the molecular structure analysis step are executed in parallel to the temperature increasing step,
wherein thermal analysis data obtained in the thermal analysis step and data obtained in the molecular structure analysis step are displayed on the same graph with temperature set as a common variable, and
wherein in the thermal analysis step, a mass variation of the sample due to the temperature increase of the sample is analyzed, the mass variation is displayed on a graph, and with respect to data obtained in the molecular structure analysis step, a thermogram of each of the generated fragment ions is displayed on the same graph as the mass variation.

Assignees

• Rigaku Denki Co Ltd

Inventors

• Arii Tadashi
• Matsushima Koichi
• Otake Satoshi

Classifications

• H01J49/0059

  by a photon beam, photo-dissociation · CPC title

• H01J49/161

  using photoionisation, e.g. by laser · CPC title

• H01J49/162

  Direct photo-ionisation, e.g. single photon or multi-photon ionisation · CPC title

• H01J49/049

  with means for applying heat to desorb the sample; Evaporation · CPC title

• H01J49/0081 Primary

  Tandem in time, i.e. using a single spectrometer · CPC title