Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates
US-9274103-B2 · Mar 1, 2016 · US
Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugate
US9689840B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9689840-B2 |
| Application number | US-201615015415-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 4, 2016 |
| Priority date | Mar 16, 2010 |
| Publication date | Jun 27, 2017 |
| Grant date | Jun 27, 2017 |
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Abstract
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Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the complexes are incorporated into chromatographic media, affinity binding reagents, and dyes, which make the complexes useful in a wide range of assays, separations, and purifications. In addition, dinuclear metal complexes of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes that are not so conjugated are used in the detection of phosphate esters of biological species by either MALDI-TOF mass spectrometry or by dye displacement.
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What is claimed is: 1. A method for the preparation of a separation medium for use in electrophoresis of phosphorylated species, said method comprising polymerizing a monomer mixture comprising acrylamide, a crosslinker, an initiator, and a compound having the formula in which: one of R 1 through R 6 is -L-R 7 in which L is a member selected from the group consisti…
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- G01N27/44747Primary
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
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- What does patent US9689840B2 cover?
- Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the complexes are incorporated into chromatographic media, affinity binding reagents, and dyes, which make the complexes useful in a wide range of assays, separations, …
- Who is the assignee on this patent?
- Bio Rad Laboratories Inc
- What technology area does this patent fall under?
- Primary CPC classification G01N27/44747. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jun 27 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).