Opioid agonists and uses thereof

Patent metadata

Field	Value
Publication number	US-9688638-B2
Application number	US-201415039686-A
Country	US
Kind code	B2
Filing date	Nov 27, 2014
Priority date	Nov 27, 2013
Publication date	Jun 27, 2017
Grant date	Jun 27, 2017

Abstract

Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

First claim

The invention claimed is:

1. A compound of Formula III:

wherein:
R is methyl, trifluoromethyl, or methyl substituted with a carboxy group;
n is an integer from 1 to 30;
and X is —O— or —NH—;

and pharmaceutically acceptable salts and solvates thereof.

2. The compound of claim 1 , wherein X is —NH—.

3. The compound of claim 1 , wherein X is —O—.

4. The compound of claim 1 , wherein n is an integer from 1 to 10.

5. The compound of claim 1 , according to Formula IV:

wherein n is an integer from 1 to 30.

6. A pharmaceutical composition comprising a compound of claim 1 and at least one pharmaceutically acceptable excipient.

7. A composition of matter comprising a compound of claim 1 , wherein the compound is present in a dosage form.

8. A method comprising administering a compound of claim 1 to a patient in need thereof.

Assignees

• Nektar Therapeutics (India) Pvt Ltd
• Nektar Therapeutics (Incorporated Under The Laws Of Delaware And Domiclled In The State Of Californi
• Nektar Therapeutics

Inventors

• Duarte Franco J
• Anand Neel K
• Sharma Pankaj
• Singh Devendrapratap

Classifications

• C07D513/08

  Bridged systems · CPC title

• C07D221/26 Primary

  Benzomorphans · CPC title

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title

• C07D401/12

  linked by a chain containing hetero atoms as chain links · CPC title