Contrast agents for applications including perfusion imaging
US-9408927-B2 · Aug 9, 2016 · US
Stabilization of radiopharmaceutical compositions using ascorbic acid
US9687571B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9687571-B2 |
| Application number | US-201013264276-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 15, 2010 |
| Priority date | Apr 15, 2009 |
| Publication date | Jun 27, 2017 |
| Grant date | Jun 27, 2017 |
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Abstract
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Radiopharmaceutical compositions, and related methods, useful for medical imaging are provided. The radiopharmaceutical compositions include one or more radiopharmaceutical compounds, together with a stabilizer comprising ascorbic acid, wherein the pH of said composition is within the range of about 3.5-5.5.
First claim
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What is claimed is: 1. A composition, comprising a radiopharmaceutical compound of formula: and ascorbic acid, wherein the pH of said composition is within a range of about 3.5 to less than 6; and wherein the composition comprises between about 25 mg/mL and 500 mg/mL of ascorbic acid. 2. The composition of claim 1 wherein the composition comprises greater than about 50 mg/mL of ascorbic acid. 3. A method for preparing a radiopharmaceutical composition of claim 1 , comprising: contacting a first solution comprising a radiopharmaceutical compound of formula: with a second solution comprising ascorbic acid within a pH range of about 3.5 to less than 6, to form the radiopharmaceutical composition comprising the radiopharmaceutical compound and ascorbic acid, wherein the composition comprises between about 25 mg/mL and 500 mg/mL of ascorbic acid. 4. A method of myocardial imaging a patient, comprising: administering to the patient a radiopharmaceutical composition comprising a radiopharmaceutical compound of formula: and ascorbic acid, wherein the pH of the composition is within a range of about 3.5 to less than 6, and wherein the composition comprises between about 25 mg/mL and 500 mg/mL of ascorbic acid; and obtaining a myocardial image of the patient. 5. The composition of claim 1 , wherein the composition comprises between about 25 mg/mL and 200 mg/mL of ascorbic acid. 6. The composition of claim 1 , wherein the composition comprises greater than about 40 mg/mL of ascorbic acid. 7. The composition of claim 1 , wherein the composition comprises between about 50 mg/mL and 200 mg/mL of ascorbic acid. 8. The composition of claim 1 , wherein the composition comprises about 50 mg/mL of ascorbic acid. 9. The composition of claim 1 , wherein said pH is within the range of about 5.5 to less than 6. 10. The composition of claim 9 , wherein the pH is 5.8. 11. The composition of claim 5 , wherein said pH is within the range of about 5.5 to less than 6. 12. The composition of claim 11 , wherein the pH is 5.8.
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Classifications
Free radical scavengers or antioxidants · CPC title
having six-membered rings with one nitrogen as the only ring hetero atom · CPC title
Pyridazines; Hydrogenated pyridazines · CPC title
having six-membered rings with one oxygen as the only ring hetero atom · CPC title
having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole · CPC title
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Frequently asked questions
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- What does patent US9687571B2 cover?
- Radiopharmaceutical compositions, and related methods, useful for medical imaging are provided. The radiopharmaceutical compositions include one or more radiopharmaceutical compounds, together with a stabilizer comprising ascorbic acid, wherein the pH of said composition is within the range of about 3.5-5.5.
- Who is the assignee on this patent?
- Castner James F, Zdankiewicz Dianne D, Anderson James E, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K51/04. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 27 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).