Antimicrobial compositions containing low concentrations of botanicals

Patent metadata

Field	Value
Publication number	US-9687429-B2
Application number	US-69411910-A
Country	US
Kind code	B2
Filing date	Jan 26, 2010
Priority date	Jun 20, 2007
Publication date	Jun 27, 2017
Grant date	Jun 27, 2017

Abstract

The present invention relates to a preservative or antimicrobial compositions with broad spectrum antimicrobial activity comprising low concentrations of essential oil (and/or one or more component thereof) and a botanical extract in synergistic combination with a fruit acid and alkanediol, and optionally a solvent. The compositions of the invention may be used in personal care products such as creams or soap products.

First claim

We claim:

1. A hand soap, hand sanitizer or hand cream composition that achieves more than about 4 Log10 reduction from control bacterial counts within 30 seconds of contact, comprising:
a. 0.01 to 0.7% w/w lemongrass oil;
b. 0.01 to 0.5% w/w orange oil;
c. 0.1 to 0.5% w/w grapefruit seed extract;
d. 0.125 to 1% w/w citric acid;
e. 0.3 to 10% w/w of a combination of octanediol and 1,3 propanediol;
f. one or more additional ingredients selected from the group consisting of: cationic surfactants, nonionic surfactants, amphoteric surfactants, cellulose polymers, cetearyl Alcohol, behentrimonium methosulfate, stearyl alcohol, glycerin, almond oil, jojoba oil, avocado oil, silicone polymers, silicone oil and combinations thereof; and
g. 0.5 to 20% w/w of an alcohol selected from the group consisting of: ethanol, isopropanol, phenoxyethanol and combinations thereof.

2. The hand soap, hand sanitizer or hand cream composition of claim 1 , wherein the one or more additional ingredients include 0.5 to 10% w/w nonionic surfactant selected from the group consisting of: poly(ethylene oxide), poly(propylene oxide), poly(ethylene oxide) block copolymer surfactant, a poloxamer, cocoamido propylamine oxide and combinations thereof.

3. The hand soap, hand sanitizer or hand cream composition of claim 1 , wherein the one or more additional ingredients include 0.05 to 2% w/w cationic surfactant selected from the group consisting of: benzalkonium chloride, guar hydroxypropyltrimonium chloride and combinations thereof.

4. The hand soap, hand sanitizer or hand cream composition of claim 1 , wherein the one or more additional ingredients include cellulose polymer selected from the group consisting of: cationic hydroxyethyl cellulose, hydroxypropyl methylcellulose and combinations thereof.

5. The hand soap, hand sanitizer or hand cream composition of claim 1 , further comprising:
i. 1 to 5% w/w aloe; and
j. 5 to 5% w/w calendula oil or extract.

6. A surface disinfectant composition that achieves more than about 4 Log10 reduction from control bacterial counts within 30 seconds of contact, comprising:
a. 0.5 to 3% w/w lemongrass oil;
b. 0.1 to 0.5% w/w orange oil;
c. 0.1 to 0.5% w/w grapefruit seed extract;
d. 0.125 to 2% w/w citric acid;
e. 0.3 to 10% w/w of a combination of octanediol and 1,3 propanediol;
f. 0.5 and 10% w/w surfactant selected from the group consisting of nonionic surfactants, cationic surfactants, amphoteric surfactants and combinations thereof;
g. 5 to 51% w/w alcohol selected from the group consisting of ethanol, isopropanol and combinations thereof; and
h. water.

7. A surface disinfectant composition that achieves more than about 4 Log10reduction from control bacterial counts within 5 minutes of contact, comprising:
a. 0.01 to 0.5% w/w lemongrass oil;
b. 0.01 to 0.5% w/w orange oil;
c. 0.01 to 0.5% w/w grapefruit seed extract;
d. 0.2 to 1% w/w citric acid;
e. 0.3 to 1% w/w of a combination of octanediol and 1,3-propanediol;
f. 0.5 to 2% w/w surfactant selected from selected from nonionic surfactants, cationic surfactants and combinations thereof;
g. 0.5 to 15% w/w alcohol selected from the group consisting of ethanol, isopropanol and combinations thereof; and
i. water.

8. A hand soap composition of claim 1 , comprising:
a. 0.01 to 0.5% w/w lemongrass oil;
b. 0.01 to 0.5% w/w orange oil;
c. 0.1 to 0.5% w/w grapefruit seed extract;
d. 0.125 to 1% w/w citric acid;
e. 1 to 10% w/w of a combination of octanediol and 1,3 propanediol;
f. 5 to 10% w/w of one or more nonionic surfactants;
g. 0.05 to 2% w/w of one or more cationic surfactants;
h. one or more cellulose polymers selected from the group consisting of: cationic hydroxyethyl cellulose, hydroxypropyl methyl cellulose and combinations thereof;
i. one or more emollients selected from the group consisting of glycerin, aloe, and calendula extract;
j. 0.1 to 1% w/w silicone polymer; and
k. 0.5 to 20% w/w of an alcohol selected from the group consisting of: ethanol, isopropanol, phenoxyethanol and combinations thereof.

9. A hand sanitizer composition of claim 1 , further comprising:
a. 0.1 to 0.2% w/w lemongrass oil;
b. 0.01 to 0.5% w/w orange oil;
c. 0.1 to 0.2% w/w grapefruit seed extract;
d. 0.125 to 1% w/w citric acid;
e. 1 to 10% w/w of a combination of octanediol and 1,3 propanediol;
f. 0.2 to 0.5% w/w hydroxypropyl methyl cellulose;
g. one or more emollients selected from the group consisting of glycerin, aloe gel, and calendula extract;
h. 0.05 to 2% cocoamido propyl betaine;
i. 0.1 to 1% w/w silicone polymer; and
j. 0.5 to 20% w/w of an alcohol selected from the group consisting of: ethanol, isopropanol, phenoxyethanol and combinations thereof.

10. A composition that achieves more than about 4 Log10 reduction from control bacterial counts within 5 minutes of contact, the composition comprising:
a. 0.1 to 0.7% w/w orange oil;
b. 0.2 to 0.5% w/w lemongrass oil;
c. 0.2 to 0.225% w/w grapefruit seed extract;
d. 0.25 to 2% citric acid;
e. 0.3 to 10% of a combination of octanediol and 1,3-propanediol; and
f. 0.5 to 20% w/w of an alcohol selected from the group consisting of: ethanol, isopropanol, phenoxyethanol and combinations thereof.

11. The composition of claim 10 , in the form of a soap, further comprising:
g. 1.5 to 11% of one or more surfactants; and
h. 1.5 to 3% of a foaming agent comprising a coconut oil based surfactant.

12. The composition of claim 10 , in the form of a surface cleaner, further comprising:
g. 1.5 to 2.1% of one or more nonionic surfactants; and
h. 0.2 to 0.5 cinnamon oil or pine oil.

13. The composition of claim 10 , in the form of a teat dip for treating mastitis, further comprising:
g. 5 to 15% glycerin;
h. 0.1 to 5% of one or more anti-irritants;
i. 0.2 to 1% of a vehicle containing gelling agent; and
j. 50 to 80% water.

14. A cleansing wipe, wound covering, wound care item or steri-strip having a surface comprising the composition of claim 10 .

15. A wipe having a surface comprising the surface cleaner composition of claim 12 .

Assignees

• Modak Shanta
• Baiju Nayana
• Caraos Lauserpina
• Univ Columbia

Inventors

• Modak Shanta
• Baiju Nayana
• Caraos Lauserpina

Classifications

• A61Q5/02

  Preparations for cleaning the hair · CPC title

• A61K8/365 Primary

  Hydroxycarboxylic acids; Ketocarboxylic acids · CPC title

• A61Q17/005

  Antimicrobial preparations · CPC title

• A61K8/922

  of vegetable origin · CPC title

• A61K31/19

  Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) · CPC title