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Methods for assessing and identifying or evolving conditionally active therapeutic proteins
US9683985B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9683985-B2 |
| Application number | US-201113200666-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 27, 2011 |
| Priority date | Sep 8, 2010 |
| Publication date | Jun 20, 2017 |
| Grant date | Jun 20, 2017 |
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Abstract
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Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo environment compared to another in vivo environment. The methods include the steps of a) testing the activity of a protein under conditions in which normal or increased activity is desired; b) testing the activity of the protein under conditions in which reduced activity compared to normal is desired; and c) comparing the activity in a) with b) and selecting/identifying a protein that has greater activity in a) compared to b). The selected/identified protein is a conditionally active protein.
First claim
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The invention claimed is: 1. An in vitro method for identifying/selecting a modified therapeutic protein that treats tumors and that has greater activity in a tumor microenvironment in a subject compared to a non-tumor environment in the subject, comprising: 1) testing the binding activity of a plurality of modified therapeutic anti-tumor proteins to the target of the therapeutic anti-tumor proteins under conditions a) and under conditions b), wherein: the modified therapeutic an…
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Human Necessities · mapped topic
- G01N33/5011Primary
Physics · mapped topic
- C07K16/30Primary
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
Physics · mapped topic
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- What does patent US9683985B2 cover?
- Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo environment compared to another in vivo environment. The methods include the steps of a) testi…
- Who is the assignee on this patent?
- Kodandapani Lalitha, Bookbinder Louis H, Frost Gregory I, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5011. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jun 20 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).