Ceramide production enhancer and moisturizer

Patent metadata

Field	Value
Publication number	US-9682029-B2
Application number	US-201615229672-A
Country	US
Kind code	B2
Filing date	Aug 5, 2016
Priority date	Oct 5, 2009
Publication date	Jun 20, 2017
Grant date	Jun 20, 2017

Abstract

A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Chenopodium hybridum, Melia toosendan, Indigofera tinctoria, Cirsium japonicum, Catalpa ovata , and Tagetes erecta , or a compound represented by the following Formula (1):

wherein, R represents an acyl group having 1 to 5 carbon atom(s).

First claim

What is claimed is:

1. A method of increasing ceramide in dry human skin, comprising applying a compound represented by the following Formula (1) to the dry skin:

wherein, R represents an acyl group having 1 to 5 carbon atom(s),
and increasing the amount of ceramide in the skin as a result of the applying.

2. The method of claim 1 , wherein R is an acyl group having 1 to 3 carbon atoms.

3. The method of claim 2 , wherein R is a formyl group, an acetyl group, a propionyl group, a butyryl group, an isobutyryl group, a valeryl group or an isovaleryl group.

4. The method of claim 3 , wherein R is a formyl group, an acetyl group or a propionyl group.

5. The method of claim 4 , wherein R is a formyl group.

6. The method of claim 1 , wherein the compound is applied in the form of an external preparation for skin that comprises the compound.

7. The method of claim 6 , wherein the compound is applied in a liquid form, solid form, emulsion form, paste form, gel form, powder form, granule form, pellet form, or stick form.

8. The method of claim 7 , wherein the external preparation for skin is a cream, lotion, gel, ointment, paste, pack, sheet-like product.

9. The method of claim 7 , wherein the preparation contains 0.00001% to 20% by mass of the compound.

10. The method of claim 1 , wherein the subject is an adult and the amount of the compound that is applied is 0.01 mg to 100 mg per day.

11. A method of moisturizing dry human skin, comprising applying a compound represented by the following Formula (1) to the dry skin:

wherein, R represents an acyl group having 1 to 5 carbon atom(s),
and moisturizing the skin as a result of the applying.

12. The method of claim 11 , wherein R is an acyl group having 1 to 3 carbon atoms.

13. The method of claim 12 , wherein R is a formyl group, an acetyl group, a propionyl group, a butyryl group, an isobutyryl group, a valeryl group or an isovaleryl group.

14. The method of claim 13 , wherein R is a formyl group, an acetyl group or a propionyl group.

15. The method of claim 14 , wherein R is a formyl group.

16. The method of claim 11 , wherein the compound is applied in the form of an external preparation for skin that comprises the compound.

17. The method of claim 16 , wherein the compound is applied in a liquid form, solid form, emulsion form, paste form, gel form, powder form, granule form, pellet form, or stick form.

18. The method of claim 17 , wherein the external preparation for skin is a cream, lotion, gel, ointment, paste, pack, sheet-like product.

19. The method of claim 17 , wherein the preparation contains 0.00001% to 20% by mass of the compound.

20. The method of claim 11 , wherein the subject is an adult and the amount of the compound that is applied is 0.01 mg to 100 mg per day.

Assignees

• Kao Corp

Inventors

• Shimotoyodome Yoshie
• Ito Shotaro
• Sugai Yoshiya
• Hashimoto Hiroshi
• Ishikawa Junko

Classifications

• A61P17/16

  Emollients or protectives, e.g. against radiation · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title

• A61K8/63 Primary

  Steroids; Derivatives thereof · CPC title