Independent magnetically-multiplexed heating of portions of a target

Patent metadata

Field	Value
Publication number	US-9681979-B2
Application number	US-201414556787-A
Country	US
Kind code	B2
Filing date	Dec 1, 2014
Priority date	Dec 1, 2013
Publication date	Jun 20, 2017
Grant date	Jun 20, 2017

Abstract

A predetermined spatial locale is selectively operationally stimulated through local heating by exposing magnetic particle(s) associated with such local to alternating magnetic field parameters of which are chosen to generate hysteretic losses in magnetic particle(s). When different types of particles are associated with different locales such as different biological cells, different cells can be accessed and stimulated independently from one another. Switching between stimulation of first and second types of cells is carried out by changing parameters of stimulating magnetic field, while optionally maintaining the field strength-frequency product substantially constant. Embodiments facilitate multiplexed release of chemical payloads, triggering changes in electrical polarization, and changing a shape of a unit placed at the chosen locale.

First claim

What is claimed is:

1. A method for magnetically-multiplexed stimulation of a region of interest (ROI) of a volume of a target, the method comprising:
delivering first and second magnetic particles to the ROI of a biological tissue of the target,

wherein the delivering includes delivering the first magnetic particles to a first neural population of a brain and delivering the second magnetic particles to a second neural population of the brain;
forming an alternating magnetic field (AMF) across the ROI, the AMF having first AMF parameters defined to selectively heat the first magnetic particles while leaving the second magnetic particles substantially unaffected by the AMF;
changing the first AMF parameters of the AMF to initiate selective heating of the second magnetic particles while substantially ceasing selective heating of the first magnetic particles; and
independently invoking neural activity in said first and second neural populations with the use of said AMF.

2. A method according to claim 1 , wherein the delivering includes delivering magnetic particles, from the first and second magnetic particles, further comprising exposing said magnetic particles to the alternating magnetic field, wherein at least one of dimensions, shapes, and compositions of said magnetic particles is configured to generate, in response to said exposing, a loss power characterizing said magnetic particles.

3. A method according to claim 2 , further comprising
varying the AMF by changing the first AMF parameters to second AMF parameters, and
changing a shape of a unit containing a shape-memory polymer in response to said varying, said unit having been placed at the ROI.

4. A method according to claim 2 , further comprising changing a polarization characteristic of an element at the ROI.

5. A method according to claim 1 , wherein the delivering includes adhering the first magnetic particles to first cells of the ROI and further includes adhering the second magnetic particles to second cells in the ROI, the first and second cells associated with different biological cascades.

6. A method according to claim 5 , further comprising changing the first AMF parameters of the AMF to second AFM parameters defined to maintain substantially constant a figure of merit that is defined by a product of amplitude and frequency of the AFM.

7. A method according to claim 1 , wherein the delivering include respectively positioning the first and second magnetic particles in a vicinity of first and second.

8. A method according to claim 1 , further comprising independently releasing at least one of first and second chemical payloads respectively associated with the first and second magnetic particles in response to said forming and said changing.

9. A method according to claim 1 , wherein the delivering ing includes delivering the first and second magnetic particles intermixed in a heat-conducting host material.

Assignees

• Massachusetts Inst Technology

Inventors

• Anikeeva Polina Olegovna
• Chen Ritchie
• Christiansen Michael Gary

Classifications

• A61N1/406 Primary

  using implantable thermoseeds or injected particles for localized hyperthermia (preparations of seeds and particles A61K41/0052) · CPC title

• A61F7/00 Primary

  Heating or cooling appliances for medical or therapeutic treatment of the human body (hyperthermia using electric or magnetic fields or ultrasound A61N) · CPC title

• A61N2/002

  in combination with another treatment · CPC title

• A61N2/004

  specially adapted for a specific therapy · CPC title

• A61N2/02

  using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) · CPC title