Silane bonded medical devices and method of making same

Patent metadata

Field	Value
Publication number	US-9681939-B2
Application number	US-201213675435-A
Country	US
Kind code	B2
Filing date	Nov 13, 2012
Priority date	Nov 18, 2011
Publication date	Jun 20, 2017
Grant date	Jun 20, 2017

Abstract

A method for bonding a graft material to a support element employing a silane coupling agent, and a medical device obtainable by the method. A medical device including a graft material bound to a support element by a plurality of silane linkages is also described.

First claim

The invention claimed is:

1. A method of bonding a sheet of graft material to a metallic support element, the method comprising:
placing the sheet of graft material in contact with the metallic support element in the presence of a silane coupling agent; and
heating the graft material, metallic support element, and silane coupling agent to an effective temperature less than a melting point of the graft material to bond the graft material to the metallic support element.

2. The method of claim 1 , wherein the graft material comprises a polymer material selected from the group consisting of polyethylene, ultra high molecular weight polyethylene, polypropylene, polyethylene terephthalate, expanded polytetrafluoroethylene, polyurethane, and polyetherurethane.

3. The method of claim 1 , wherein the metallic support element comprises a metallic material selected from the group consisting of a nickel-titanium alloy, stainless steel, and a cobalt-chromium alloy, and the graft material is bonded to the metallic material.

4. The method of claim 3 , wherein the metallic support element comprises a nickel-titanium alloy.

5. The method of claim 1 , wherein the silane coupling agent is a compound of formula Ia:

wherein:
X 1 , X 2 , and X 3 are independently selected from the group consisting of C 1 -C 4 alkoxy, C 1 -C 4 acyloxy, Cl, Br, and I; and
L is a bond or a substituted or unsubstituted C 1 -C 6 alkanediyl group.

6. The method of claim 5 , wherein the silane coupling agent is vinyltrimethoxysilane.

7. The method of claim 5 , wherein said heating the graft material, metallic support element, and silane coupling agent is conducted in the presence of a radical initiator.

8. The method of claim 7 , wherein the radical initiator is a peroxide selected from the group consisting of dibenzyl peroxide and dicumyl peroxide.

9. The method of claim 5 , wherein said heating the graft material, metallic support element, and silane coupling agent is performed under high humidity conditions.

10. The method of claim 1 , wherein the silane coupling agent is a compound of formula Ib:

wherein:
X 1 , X 2 , and X 3 are independently selected from a group consisting of C 1 -C 4 alkoxy, C 1 -C 4 acyloxy, Cl, Br, and I;
Y is selected from the group consisting of SO 2 , C(O), OC(O), and a bond; and
L is selected from a group consisting of a substituted or unsubstituted alkanediyl group, (CH 2 ) n (C 6 H 4 )(CH 2 ) p , wherein n=an integer between 0 and 4, and p=an integer between 2 and 4.

11. The method of claim 10 , wherein Y is selected from the group consisting of SO 2 , C(O), and OC(O).

12. The method of claim 11 , wherein Y is SO 2 .

13. The method of claim 12 , wherein the silane coupling agent is 6-azidosulfonylhexyltriethoxysilane.

14. The method of claim 1 , wherein said placing the graft material in contact with the metallic support element in the presence of a silane coupling agent comprises:
applying the silane coupling agent to the graft material to form a treated graft material; and
placing the treated graft material in contact with the metallic support element.

15. The method of claim 1 , wherein said placing the graft material in contact with the metallic support element in the presence of a silane coupling agent comprises:
applying the silane coupling agent to the metallic support element to form a treated support element; and
placing the graft material in contact with the treated support element.

16. The method of claim 1 , wherein said placing the graft material in contact with the metallic support element in the presence of a silane coupling agent comprises;
placing the graft material in contact with the metallic support element; and
applying the silane coupling agent to the graft material and the metallic support element.

Assignees

• Grewe David Douglas
• Haselby Kenneth Aaron
• Milner Keith
• Sherman Sara Marie
• Cook Medical Technologies Llc

Inventors

• Grewe David Douglas
• Haselby Kenneth Aaron
• Milner Keith
• Sherman Sara Marie

Classifications

• A61L2420/02

  Methods for coating medical devices · CPC title

• A61L31/022

  Metals or alloys · CPC title

• A61L31/10 Primary

  Macromolecular materials · CPC title

• A61F2/07 Primary

  Stent-grafts · CPC title

• C08L83/04

  Polysiloxanes · CPC title