Metal-ligand coordination polymer nanoparticles and methods for making

Patent metadata

Field	Value
Publication number	US-9677075-B2
Application number	US-201414786569-A
Country	US
Kind code	B2
Filing date	Apr 23, 2014
Priority date	Apr 23, 2013
Publication date	Jun 13, 2017
Grant date	Jun 13, 2017

Abstract

Disclosed herein are metal-ligand complexes containing polynucleotides, compounds for making the same, and methods of using the same.

First claim

What is claimed:

1. A compound having a structure:

wherein R is OH or —O—C(O)—NAr 2 , each Ar is aryl, and n is 1 or 2.

2. The compound of claim 1 , wherein n is 1 and the pyridone moiety is attached to the phenyl at the para position.

3. The compound of claim 1 , wherein n is 2 and the pyridone moieties are attached to the phenyl at the meta positions.

4. A polynucleotide comprising at a terminus a moiety comprising:

wherein R is OH or —O—C(O)—NAr 2 , each Ar is aryl, n is 1 or 2, and Alkylene comprises 6-20 carbons.

5. The polynucleotide of claim 4 , wherein n is 1 and the pyridone moiety is attached to the phenyl at the para position.

6. The polynucleotide of claim 4 , wherein n is 2 and the pyridone moieties are attached to the phenyl at the meta positions.

7. A metal-ligand complex comprising the polynucleotide of claim 4 and iron (III).

8. A supramolecular complex comprising a first metal-ligand complex of claim 7 and a second metal-ligand complex of claim 7 , wherein the first metal-ligand complex comprises a first polynucleotide and the second metal-ligand complex comprises a second polynucleotide that is sufficiently complementary to the first polynucleotide to hybridize under appropriate conditions.

9. A method of inhibiting expression of a gene product encoded by a target polynucleotide comprising contacting the target polynucleotide with the supramolecular complex of claim 8 under conditions sufficient to inhibit expression of the gene product.

Assignees

• Univ Northwestern

Inventors

• Mirkin Chad A
• Calabrese Colin Michael
• Morris William

Classifications

• C07H21/00

  Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids · CPC title

• G01N33/54346 Primary

  Nanoparticles · CPC title

• A61K31/7088

  Compounds having three or more nucleosides or nucleotides · CPC title

• C12Q1/68

  involving nucleic acids · CPC title

• C07F15/02

  Iron compounds · CPC title