Implantable heart treatment systems, devices, and methods

Patent metadata

Field	Value
Publication number	US-9675812-B2
Application number	US-201514676095-A
Country	US
Kind code	B2
Filing date	Apr 1, 2015
Priority date	Apr 1, 2015
Publication date	Jun 13, 2017
Grant date	Jun 13, 2017

Abstract

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart.

First claim

What is claimed is:

1. An implantable heart treatment device, comprising:
a substrate configured for implantation within a body;
an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body;
a metabolic molecule supply device coupled to the substrate and configured to supply one or more metabolic molecules to one or more tissues of the heart within the body; and
control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals upon execution of the first control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals and to generate one or more control signals that cause the metabolic molecule supply device to supply the one or more metabolic molecules upon execution of the second control protocol, wherein the control circuitry is configured to execute the first control protocol during a fibrillation event of the heart and prior to exhaustion of myoglobin-based oxygen storage of the heart.

2. The implantable heart treatment device of claim 1 , wherein the one or more metabolic molecules include one or more oxygenated molecules.

3. The implantable heart treatment device of claim 1 , wherein the one or more metabolic molecules include iodide or salts thereof.

4. The implantable heart treatment device of claim 1 , wherein the metabolic molecule supply device includes a high surface area exchanger configured to transfer the one or more metabolic molecules to blood in contact with the high surface area exchanger.

5. The implantable heart treatment device of claim 1 , wherein the metabolic molecule supply device is further configured to deliver one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body.

6. The implantable heart treatment device of claim 5 , wherein the one or more non-oxygen cellular energy sources include at least one of adenosine triphosphate (ATP), cyclic adenosine monophosphate (cAMP), adenosine monophosphate (AMP), adenosine diphosphate (ADP), creatine, and cyclocreatine.

7. The implantable heart treatment device of claim 1 , wherein the control circuitry is configured to execute the second control protocol at least one of following execution of the first control protocol or after executing the first control protocol for a predefined time period.

8. The implantable heart treatment device of claim 1 , wherein the control circuitry is configured to at least one of execute at least one of the first control protocol and the second control protocol responsive to one or more commands from an external device, cease execution of at least one of the first control protocol and the second control protocol responsive to one or more commands from the external device, or generate the one or more controls signals to activate one or more of the electromagnetic signal generator and the metabolic molecule supply device responsive to one or more commands from an external device.

9. An implantable heart treatment device, comprising:
a substrate configured for implantation within a body;
an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body;
a metabolic molecule supply device coupled to the substrate and configured to supply one or more metabolic molecules to one or more tissues of the heart within the body; and
control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals upon execution of the first control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals and to generate one or more control signals that cause the metabolic molecule supply device to supply the one or more metabolic molecules upon execution of the second control protocol, wherein the control circuitry is configured to execute the second control protocol during a fibrillation event of the heart after the fibrillation event has proceeded for a duration sufficient to substantially exhaust the myoglobin-based oxygen of the heart.

10. An implantable heart treatment device, comprising:
a substrate configured for implantation within a body;
an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body;
a metabolic molecule supply device coupled to the substrate and configured to supply one or more metabolic molecules to one or more tissues of the heart within the body; and
control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals upon execution of the first control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals and to generate one or more control signals that cause the metabolic molecule supply device to supply the one or more metabolic molecules upon execution of the second control protocol, wherein the control circuitry is configured to execute the first control protocol during a period from onset of a fibrillation event of the heart until between approximately fifty seconds and seventy-five seconds following onset of the fibrillation event.

11. An implantable heart treatment device, comprising:
a substrate configured for implantation within a body;
an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body;
a metabolic molecule supply device coupled to the substrate and configured to supply one or more metabolic molecules to one or more tissues of the heart within the body; and
control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals upon execution of the first control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals and to generate one or

Assignees

• Elwha Llc

Inventors

• Hyde Roderick A
• Jung Edward K Y
• Leuthardt Eric C
• Mcknight Gary L
• Wood Jr Lowell L

Classifications

• A61N1/3962

  in combination with another heart therapy · CPC title

• A61M2202/0275

  Nitric oxide [NO] · CPC title

• A61M2202/0283

  Nitrous oxide (N2O) · CPC title

• A61M2202/0233

  Carbon monoxide · CPC title

• A61N1/3629

  in combination with non-electric therapy · CPC title