Methods of providing antioxidants to a drug containing product

Patent metadata

Field	Value
Publication number	US-9675737-B2
Application number	US-85142010-A
Country	US
Kind code	B2
Filing date	Aug 5, 2010
Priority date	Jul 25, 2005
Publication date	Jun 13, 2017
Grant date	Jun 13, 2017

Abstract

A method of providing an antioxidant to a medical device and a kit are described.

First claim

What is claimed is:

1. A kit, comprising:
a pouch;
a medical device with a drug in the pouch;
a porous or permeable container in the pouch; and
an antioxidant in the porous or permeable container such that the medical device with the drug is placed outside of the porous or permeable container;
wherein the antioxidant is a volatile antioxidant and evaporates and fills the space of the pouch.

2. The kit according to claim 1 , wherein the antioxidant comprises butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA) or a combination thereof.

3. The kit according to claim 1 , wherein the antioxidant is of a type to sublime to form a gas that permeates out from the container.

4. The kit according to claim 1 ,
wherein the antioxidant of claim 1 is a first antioxidant; and
wherein the medical device or the drug comprises a second antioxidant, the second antioxidant being the same as or different than the first antioxidant, such that the first antioxidant is adapted to be added to the medical device or the drug subsequent to a loss of the second antioxidant from the medical device or the drug during the life of the medical device or the drug in the pouch.

5. The kit according to claim 1 , wherein the medical device comprises a stent.

6. The kit according to claim 1 , wherein the medical device comprises a coated stent.

7. The kit according to claim 1 , wherein the coating comprises the drug.

8. The kit according to claim 7 , wherein the drug is selected from the group consisting of paclitaxel, docetaxel, estradiol, nitric oxide donors, super oxide dismutases, super oxide dismutases mimics, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), tacrolimus, dexamethasone, rapamycin, rapamycin derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (everolimus), pimecrolimus, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-O-tetrazole-rapamycin, 40-epi-(N1-tetrazolyl)-rapamycin (ABT-578), imatinib mesylate, midostaurin, clobetasol, bioactive RGD, CD-34 antibody, abciximab (REOPRO), progenitor cell capturing antibody, and prodrugs and combinations thereof.

9. The kit of claim 6 , wherein the coated stent is crimped on a delivery catheter or a balloon catheter.

10. The kit according to claim 1 , wherein the medical device comprises a coating which comprises a biocompatible polymer.

11. The kit according to claim 10 , wherein the biocompatible polymer is selected from the group consisting of poly(ester amide), ethylene vinyl alcohol copolymer, poly(D,L-lactide) (PDLLA), poly(D,L-lactic acid-co-glycolic acid) (PDLLGA), polyglycolic acid (PGA), polyhydroxyalkanoate (PHA), poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), poly(3-hydroxyvalerate), poly(3-hydroxyhexanoate), poly(4-hydroxybutyrate), poly(4-hydroxyvalerate), poly(4-hydroxyhexanoate), poly(D,L-lactide), poly(L-lactide), polycaprolactone (PCL), polydioxanone, polyorthoester, polyanhydride, poly(glycolic acid-co-trimethylene carbonate), and a combination thereof.

Assignees

• Ding Ni
• Abbott Cardiovascular Systems Inc

Inventors

• Ding Ni

Classifications

• A61L31/10 Primary

  Macromolecular materials · CPC title

• Y10T428/1307

  Bag or tubular film [e.g., pouch, flexible food casing, envelope, etc.] · CPC title