Electroporation of tissue products
US-2015343101-A1 · Dec 3, 2015 · US
US9675718B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9675718-B2 |
| Application number | US-201314649242-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 29, 2013 |
| Priority date | Dec 3, 2012 |
| Publication date | Jun 13, 2017 |
| Grant date | Jun 13, 2017 |
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The present invention relates to an irradiation device for irradiating objects with electron beams. The irradiation device comprises at least one electron beam emitter having an electron exit window and at least one sensor device for detecting a first dose control parameter of the electron beam. The electron beam emitter is adapted to move past the sensor device such that the electron beam emitted from the electron exit window passes within a sensing area of the sensor device. The sensor device comprises more than one conductor each having a conductor surface in the sensing area of the sensor device, and the conductor surface is adapted to be exposed to electrons of the electron beam. The invention also relates to a method.
Opening claim text (preview).
The invention claimed is: 1. Irradiation device for irradiating objects with electron beams, the irradiation device comprises at least one electron beam emitter having an electron exit window, at least one sensor device for detecting a first dose control parameter of the electron beam, wherein, the electron beam emitter is adapted to move past the sensor device such that the electron beam emitted from the electron exit window passes within a sensing area of the sensor device, and the sensor device comprises more than one conductor each having a conductor surface in the sensing area of the sensor device, which conductor surface is adapted to be exposed to electrons of the electron beam. 2. The irradiation device according to claim 1 , wherein the first dose control parameter is electrical current and wherein the sensor device is connected to a current signal module adapted to measure any electrical current from each of the conductors, the current signal module is in communication with a dose processing module, and the dose processing module is adapted to collect first dose control parameter measurements made at different times, during the passage of the electron beam over the sensor device, to generate an image of the electron beam. 3. The irradiation device according to claim 2 , wherein the first dose control parameter is processed, in the dose processing module, together with second dose control parameters to create dose information comprising dose rate (kGy/s) per area unit of the electron beam delivered from the electron beam emitter in the sensing area, and wherein the second dose control parameters comprise current and voltage fed to the electron beam emitter and position of the electron beam emitter in relation to each conductor of the sensor device. 4. The irradiation device according to claim 3 , wherein the support is connected to a voltage potential and is partly surrounding the conductors to form a plasma shield. 5. The irradiation device according to claim 3 , wherein each conductor is a pin arranged through a hole in the support, that the exposed conductor surface is formed by a surface in a first end of the pin, and that the second end of the pin is connected to an insulated electrical cable, which cable exits the support and connects to the current signal module. 6. The irradiation device according to claim 3 , wherein each conductor is a pin arranged through a hole in the support, that the exposed conductor surface is formed by a surface in a first end of the pin, and that the second end of the pin exits the support and forms a portion of a male part of a shielded pin connector, and wherein a female part of the shielded pin connector is adapted to be connected to the male part of the shielded pin connector and that a cable from the female part of the shielded pin connector is connected to the current signal module. 7. The irradiation device according to claim 2 , wherein the dose processing module is in communication with an emitter control module and an irradiation control module, the second dose control parameters are adapted to be sent to the dose processing module from the emitter control module and the irradiation control module, the emitter control module is connected to means for measuring the current over a filament of the electron beam emitter and the voltage between the electron exit window and the filament, and the dose processing module is adapted to provide a feedback signal to the irradiation control module if the dose rate in one or several of the area units is not within an acceptable, pre-set dose rate range. 8. The irradiation device according to claim 1 , wherein the conductors of the sensor device are arranged along a line being directed substantially perpendicular to a direction of the movement of the electron beam emitter over the sensor device, and the sensor device comprises a support in which the conductors are arranged, and wherein the conductors are electrically insulated from the support. 9. The irradiation device according to claim 8 , wherein the sensing area of the sensor device at least covers the extension of the entire electron beam in a plane of the sensing area and wherein the first control parameter is detected once during the passage of the electron beam over the sensor device. 10. The irradiation device according to claim 1 , wherein a first set of exposed conductor surfaces are arranged in a common first plane, the first plane being a first sensor surface and is aligned with a first portion of the sensing area, and the electron beam emitter and the sensor device are arranged such, in relation to each other, that when the electron beam emitter passes over the sensor device a plane, corresponding to the surface of the electron exit window, is moved in a direction parallel to the first plane of the sensor device. 11. The irradiation device according to claim 10 , wherein a second set of exposed conductor surfaces are arranged in a common second plane, the second plane being a second sensor surface, being parallel to the first plane and spaced from the first plane in a direction substantially perpendicular to the plane of the electron exit window and away from the plane of the electron exit window, and being aligned with a second portion of the sensing area, and wherein the exposed conductor surfaces of the second set are arranged one after the other along a line, the line being aligned with the first direction. 12. The irradiation device according to claim 1 , wherein the sensing area has a length in a first direction being larger than a longest extension of an area, along the first direction, passed by the electron beam, when the electron exit window is moved past the sensing area in a second direction being either perpendicular to the first direction or angled in relation to the first direction, the exposed conductor surfaces of the first set are arranged one after the other along a line, and the line is aligned with the first direction. 13. The irradiation device according to claim 1 , wherein it is provided in a filling machine for use in sterilization of packaging containers, and comprises a first position being a packaging container infeed point, and a second position being a packaging container outfeed point, wherein, the electron beam emitter is adapted to perform a first movement from the first position to the second position, and during the first movement the electron beam emitter is adapted to be at least temporarily engaged with a packaging container for irradiating the packaging container, and the electron beam emitter is adapted to perform a second movement from the second position to the first position, and during the second movement the electron beam emitter is adapted to move past the sensor device such that the electron beam emitted from the electron exit window is adapted to be at least temporarily located within a sensing area of the sensor device. 14. Method for irradiating objects with an electron beam, the method comprising: moving at least one electron beam emitter, which emits an electron beam through an electron exit window of the at least one electron beam emitter, past at least one sensor device, which detects a first dose control parameter of the electron beam, the sensor device comprising more than one conductor each having a conductor surface in a sensing area of the sensor device; the at least one electron beam emitter being moved past the at least one sensor device such that the electron beam emitted from the electron exit window passes within the sensing area of the at least one sensor device; and exposing, to the elect
Dosimeters (G01T1/15 takes precedence) · CPC title
Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs · CPC title
Containers other than laboratory or medical, e.g. bottles or mail · CPC title
by irradiation · CPC title
Discharge tubes with provision for emergence of electrons or ions from the vessel ({irradiation devices G21K} ; particle accelerators H05H); Lenard tubes · CPC title
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