Nitrogen-containing heterocyclic compound
US-2015307497-A1 · Oct 29, 2015 · US
US9675597B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9675597-B2 |
| Application number | US-201615291769-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 12, 2016 |
| Priority date | Apr 23, 2014 |
| Publication date | Jun 13, 2017 |
| Grant date | Jun 13, 2017 |
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The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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The invention claimed is: 1. A method for the treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia or dementia with Lewy bodies in a mammal, which comprises administering an effective amount of 4-fluoro-2-[(3S,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]-5-methyl-6-[4-(1H-pyrazol-1-yl)benzyl]-2,3-dihydro-1H-isoindol-1-one or a salt thereof to the mammal.
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