D3 dopamine receptor agonists to treat dyskinesia in parkinson's disease

Patent metadata

Field	Value
Publication number	US-9675565-B2
Application number	US-201313957861-A
Country	US
Kind code	B2
Filing date	Aug 2, 2013
Priority date	Aug 11, 2010
Publication date	Jun 13, 2017
Grant date	Jun 13, 2017

Abstract

The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.

First claim

What is claimed is:

1. A pharmaceutical composition comprising at least one compound selected from the group consisting of:
2-amino-4-(2-chlorophenyl)butan-1-ol;
2-(3-aminohexyl)phenol;
4-(2-chlorophenyl)-butan-2-amine;
4-(2-chlorophenyl)-2-methylamino-butane;
4-(2-fluorophenyl)butan-2-amine;
4-(2-bromophenyl)butan-2-amine;
4-(2-iodophenyl)butan-2-amine;
4-(2-methoxyphenyl)butan-2-amine;
3-(3,4-diethoxyphenyl)propan-1-amine;
4-(4-chlorophenyl)butan-2-amine;
4-(4-methoxyphenyl)butan-2-amine;

any mixtures thereof; and any pharmaceutically acceptable salts thereof.

2. A compound selected from the group consisting of:
2-amino-4-(2-chlorophenyl)butan-1-ol;
2-(3-aminohexyl)phenol;
4-(2-iodophenyl)butan-2-amine;
4-(2-methoxyphenyl)butan-2-amine;
4-(4-chlorophenyl)butan-2-amine;
any mixtures thereof; and any pharmaceutically acceptable salts thereof.

3. A pharmaceutical composition comprising 4-(2-chlorophenyl)-butan-2-amine, or a pharmaceutically acceptable salt thereof.

Assignees

• Univ Drexel
• Univ Rutgers

Inventors

• Kortagere Sandhya
• Kuzhikandahil Eldo V

Classifications

• A61P25/14

  for treating abnormal movements, e.g. chorea, dyskinesia · CPC title

• A61P25/16

  Anti-Parkinson drugs · CPC title

• A61K31/48

  Ergoline derivatives, e.g. lysergic acid, ergotamine · CPC title

• A61K31/4184

  condensed with carbocyclic rings, e.g. benzimidazoles · CPC title

• C07D471/04

  Ortho-condensed systems · CPC title