System and method for mass spectrometry imaging
US-2024389905-A1 · Nov 28, 2024 · US
US9675417B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9675417-B2 |
| Application number | US-200913003022-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 10, 2009 |
| Priority date | Jul 15, 2008 |
| Publication date | Jun 13, 2017 |
| Grant date | Jun 13, 2017 |
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Official abstract text for this publication.
The present invention relates to a device comprising a supply unit ( 2 ) for supplying ablation energy to a material ( 4 ), and a stimuli-responsive substance ( 3 ′) for controlling a level of the ablation energy deposited into the material ( 4 ). The device allows to limit a temperature of the material ( 4 ), so that risks associated to ablation at too high temperatures can be eliminated. The device may comprise at least one illumination unit ( 7 ) for illuminating the material ( 4 ), and at least one reception unit ( 8 a, 8 b ) for receiving reflected light in order to obtain information about a state of the material ( 4 ). The obtained information can be used to regulate the supplied ablation energy.
Opening claim text (preview).
The invention claimed is: 1. Device comprising: a supply unit configured to supply ablation energy to a material; and a container comprising a stimuli-responsive substance adjacent the material; wherein said stimuli-responsive substance is configured to change its state from a first state to a second state if a temperature of said material increases above an upper threshold temperature due to at least a portion of said ablation energy passing through said stimuli-responsive substance into the material, so that said temperature of said material does not increase above a temperature limit a cooling system configured to cool said device, wherein said stimuli-responsive substance is configured to change its geometrical properties in order to control said cooling system. 2. Device according to claim 1 , wherein said stimuli-responsive substance is configured to change its state back from said second state to said first state if said temperature of said material decreases below a lower threshold temperature. 3. Device according to claim 1 , wherein said stimuli-responsive substance is a temperature-sensitive gel. 4. Device according to claim 1 , wherein said stimuli-responsive substance is configured to change its optical properties from being transparent to being scattering and/or absorbing if said temperature of said material increases above said upper threshold temperature. 5. Device according to claim 1 , wherein said cooling system comprises at least one inflow pipe and at least one outflow pipe, and wherein said container comprises at least one flexible portion configured to disable a connection between said at least one inflow pipe and said at least one outflow pipe at least partially if said temperature of said material is equal to or below said upper threshold temperature and to enable said connection if said temperature of said material increases above said upper threshold temperature. 6. Device according to claim 1 , wherein said cooling system comprises at least one portion configured to extend around said supply unit. 7. Device according to claim 1 , wherein said supply unit is a fiber and said ablation energy is laser energy. 8. Device according to claim 1 , wherein said device is a catheter or a needle. 9. Method comprising: supplying ablation energy to a material; changing a state of a stimuli-responsive substance adjacent the material from a first state to a second state if a temperature of said material increases above an upper threshold temperature due to at least a portion of said ablation energy passing through said stimuli-responsive substance into the material, so that said temperature of said material does not increase above a temperature limit; and controlling a cooling system for cooling a device supplying the ablation energy, the stimuli-responsive substance being configured to change its geometrical properties in order to control the cooling system.
with a catheter (A61B18/26, A61B18/28 take precedence) · CPC title
Temperature · CPC title
having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence) · CPC title
Light · CPC title
Temperature · CPC title
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