Double fortified salt composition containing iron and iodine and process for the preparation thereof

Patent metadata

Field	Value
Publication number	US-9675098-B2
Application number	US-201314382521-A
Country	US
Kind code	B2
Filing date	Mar 4, 2013
Priority date	Mar 2, 2012
Publication date	Jun 13, 2017
Grant date	Jun 13, 2017

Abstract

The present invention relates to stable and white iron fortification and iron+iodine double fortification agents, their preparation and use in fortification of salt. These agents help overcome the normal difficulties encountered in iron and iodine fortification such as low iodine stability on storage, development of colour and odour, and use of unwanted additives to impart stability. In one of the invented products, both iron and iodine coexist in stable manner in the same matrix which allow for a more uniform distribution of iodine. The process of preparation is demonstrated to be scalable and utilizes commonly available raw materials which would enable the products to be synthesized in affordable manner.

First claim

We claim:

1. A fortifying agent, for edible salt wherein the fortifying agent is of compound of formula (1a) or formula (1b):
[Mg 4.3±0.4 Fe(III)(OH) 10.6±0.8 ][CO 3 ] 0.5 .3H 2 O  (1a),

or
[Mg 4.3±0.4 Fe(III)(OH) 10.6±0.8 ](CO 3 ) 0.486 (IO 3 ) 0.016±0.002 .3H 2 O  (1b)

wherein the compound of formula (1a) has a magnetic moment of 1.49 B.M., and 13-15% low spin Fe(III) (w/w); and the compound of formula (1b) has a magnetic moment of 1.339 B.M., 13-15% low spin Fe(III) (w/w) and 0.4-0.6% (w/w) I.

2. A process for preparing the fortifying agent as claimed in claim 1 comprising the steps of:
(i) preparing a slurry by mixing aqueous FeCl 3 solution into aqueous Na 2 CO 3 solution at a temperature of 25 to 35° C.;
(ii) adding the slurry obtained in step (i) into an aqueous Mg(OH) 2 slurry to obtain a [Mg]:[Fe]ratio of 3.95 to 4.75 at a temperature of 25 to 35° C.;
(iii) adjusting a pH of the slurry obtained in step (ii) with additional amounts of Na 2 CO 3 to keep the pH of 9.0-10 to give a pH-adjusted slurry;
(iv) charging the pH-adjusted slurry from step (iii) into a pressure reactor for hydrothermal treatment at a temperature of 140 to 150° C. for a period of 4to 5 hours followed by cooling at a temperature of 50 to 60° C., filtering and washing a white solid cake obtained with water to remove electrolytes to give it washed white solid cake, and ensuring a pH of wash water <10;
(v) drying the washed white solid cake obtained in step (iv) at a temperature of 105-115°C. to form a dry product; and
(vi-a) pulverizing the dry product from step (v) to give a pulverized product, and passing the pulverized product through −30 to +72 BSS mesh to obtain the compound of formula (1a)
[Mg 4.3±0.4 Fe(III)(OH) 10.6±0.8 ][CO 3 ] 0.5 .3H2O  (1a); or

(vi-b) calcining the dry product obtained in step (v) at a temperature of 440-460° C. for a period of 1 to 2 hr, cooling at temperature of 50 to 60° C. and contacting with 1 mM aqueous KIO 3 solution under stirring for a period of 4 to 5 min, leaving to stand thereafter for a period of 12 to 16 hours followed by separating a solid and washing the solid free of adhering iodate, drying at a temperature of 100 to 110° C. to obtain the compound of formula (1b)
[Mg 4.3±0.4 Fe(III)(OH) 106±0.8 ](CO 3 ) 0.486 (IO 3 ) 0.016±0.002 .3H 2 O  (1b).

3. The process as claimed in claim 2 , wherein the pH of the slurry in step (iii) is adjusted to 9.0-9.5.

4. The process as claimed in claim 2 , wherein sea or sub-soil bittern is utilized as a magnesium source.

5. An iron fortified salt, fortified with the compound of formula (1a) of claim 1 .

6. A double fortified salt, fortified with the compound of formula (1b) of claim 1 , having an Fe content of 1000-1200 ppm and an I content of 30-40 ppm.

7. The double fortified salt of claim 6 , which is white in appearance and remains so after 12 months of storage with negligible loss of iodine.

8. The double fortified salt of claim 6 , wherein both Fe and I have a uniformity of distribution in the double fortified salt wherein an amount of iron and iodine in a kg of the double fortified salt is spread over 8 g of the fortifying agent.

9. The fortifying agent as claimed in claim 1 , wherein the fortifying agent disintegrates spontaneously in 5-10 minutes in a solution of 0.068M HCl.

10. A double fortified sat, fortified with the compound of formula (1a) of claim 1 and iodate exchanged synthetic hydrotalcite with 5-6% w/w iodine loading.

11. The double fortified salt of claim 10 , which has 1000-1200 ppm Fe and 38-40 ppm I, and is white in colour.

12. The double fortified salt of claim 10 , wherein the iron is spread over 8-9 g and the iodine is spread over 0.5-0.6 g of the fortifying, agent.

Assignees

• Council Scient Ind Res

Inventors

• Chunawala Jatin Rameshchandra
• Ghosh Pushpito Kumar
• Gandhi Maheshkumar Ramniklal
• Mehta Satish Hariray
• Sheth Mrunalben Vinodray
• MONDAL Dibyendu

Classifications

• A23L33/17 Primary

  Amino acids, peptides or proteins · CPC title

• A23L33/16

  Inorganic salts, minerals or trace elements · CPC title

• C01P2006/42

  Magnetic properties · CPC title

• C01P2002/72

  by d-values or two theta-values, e.g. as X-ray diagram · CPC title

• C01G49/009 Primary

  Compounds containing iron, with or without oxygen or hydrogen, and containing two or more other elements · CPC title