GluN2C/D Subunit Selective Antagonists of the N-Methyl-D-Aspartate Receptor
US-2024294493-A1 · Sep 5, 2024 · US
Neprilysin inhibitors
US9670140B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9670140-B2 |
| Application number | US-201514792810-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 7, 2015 |
| Priority date | Jun 8, 2012 |
| Publication date | Jun 6, 2017 |
| Grant date | Jun 6, 2017 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
In one aspect, the invention relates to compounds having the formula XII: where R a , R b , R 2 , R 7 , and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound of: (a) (2R,4R)-4-amino-5-(3′-chlorobiphenyl-4-yl)-2-hydroxypentanoic acid ethyl ester; (b) (2R,4R)-4-amino-5-(3′-chlorobiphenyl-4-yl)-2-hydroxypentanoic acid 2,2,3,3,3-pentafluoropropyl ester; (c) (2R,4R)-4-amino-5-(3′-chlorobiphenyl-4-yl)-2-hydroxypentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester; or (d) (2R,4R)-4-amino-5-(3′-chlorobiphenyl-4-yl)-2-hydroxypentanoic acid butyryloxymethyl ester. 2. A compound of: (a) (2R,4R)-4-amino-5-(5′-chloro-2′-fluoro-biphenyl-4-yl)-2-hydroxypentanoic acid; (b) (2R,4R)-4-amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxypentanoic acid ethyl ester; (c) (2R,4R)-4-amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxypentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester; (d) (2R,4R)-4-amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxypentanoic acid 2,2,3,3,3-pentafluoropropyl ester; or (e) (2R,4R)-4-amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxypentanoic acid butyryloxymethyl ester.
Assignees
Inventors
Classifications
Antihypertensives · CPC title
Drugs for disorders of the cardiovascular system · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title
Drugs for disorders of the urinary system · CPC title
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Frequently asked questions
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- What does patent US9670140B2 cover?
- In one aspect, the invention relates to compounds having the formula XII: where R a , R b , R 2 , R 7 , and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprisi…
- Who is the assignee on this patent?
- Hughes Adam D, Theravance Biopharma R&D Ip Llc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/415. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 06 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).